Cell adhesion/recognition and signal transduction through glycosphingolipid microdomain
Cell adhesion/recognition and signal transduction through glycosphingolipid microdomain
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DOI：
10.1023/a:1026524820177
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发表时间：
2000-03-01
影响因子：
3
通讯作者：
Hakomori, S
中科院分区：
文献类型：
--
作者：
Hakomori, S
动物细胞中的鞘糖脂 (GSL) 和鞘磷脂聚集并组织为膜微域，与各种信号转导分子如 cSrc、Src 家族激酶、小 G 蛋白（例如 RhoA、Ras）和粘着斑激酶密切相关。通过碳水化合物与碳水化合物的相互作用，GSL 聚集在此类微域中，导致与对应细胞表面或塑料表面上的互补 GSL 粘附。微域中的 GEL 依赖性细胞粘附会导致信号转导器激活，从而导致细胞表型变化。回顾了这一概念的发展以及我们的研究现状。
Glycosphingolipids (GSLs) and sphingomyelin in animal cells are clustered and organized as membrane microdomains closely associated with various signal transducer molecules such as cSrc, Src family kinases, small G-proteins (e.g., RhoA, Ras), and focal adhesion kinase. GSL clustering in such microdomains causes adhesion to complementary GSLs on the surface of counterpart cells or presented on plastic surfaces, through carbohydrate-to-carbohydrate interaction. GEL-dependent cell adhesion In microdomain causes activation of the signal transducers, leading to cell phenotypic changes. A retrospective of the development of this concept, and current status of our studies, are presented.