Can an antihistamine delay appearance of hay fever symptoms when given prior to pollen season?
Can an antihistamine delay appearance of hay fever symptoms when given prior to pollen season?
复制标题
在花粉季节之前服用抗组胺药可以延迟花粉热症状的出现吗？
DOI：
10.1111/j.1398-9995.1997.tb01026.x
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发表时间：
1997
期刊：
影响因子：
12.4
通讯作者：
D. Tudor
中科院分区：
文献类型：
--
作者：
M. Stern;R. Darnell;D. Tudor
咪唑斯汀是一种新型的非镇静抗组胺药，可有效缓解过敏性疾病的症状。本研究的目的是确定如果在花粉季节之前给予咪唑斯汀，是否可以延迟已知患有季节性过敏性鼻结膜炎症状的患者的花粉热症状发作。这项双盲研究涉及342例患者，随机分配至每日一次10 mg咪唑斯汀（n= 115）、每日一次120 mg特非那定（n= 116）或安慰剂（n= 111）组。所有患者均于5月1日，即草花粉季节到来之前开始治疗。根据试验药物延迟至本季节首次花粉热危象时间的能力评估试验药物的预防作用，首次花粉热危象定义为发生以下事件之一：使用急救药物、因治疗失败退出研究或日记症状总评分超过18。与安慰剂（50天）相比，活性药物治疗使至首次危象的时间延长约1周（咪唑斯汀55天，特非那定57天）（生存曲线分析：对数秩检验，P= 0.01; Wilcoxon检验，P= 0.03）。耐受性令人满意，组间相当。因此，咪唑斯汀可以安全地用于延迟和治疗季节性过敏性鼻炎的症状。
Mizolastine is a new, nonsedating antihistamine providing satisfactory symptom relief in allergic conditions. The purpose of this study was to determine whether the onset of hay fever symptoms could be delayed in patients known to suffer seasonal allergic rhinoconjunctivitis symptoms if mizolastine was given before the pollen season. This double‐blind study involved 342 patients, randomly allocated to once‐daily 10 mg mizolastine (n= 115), once‐daily 120 mg terfenadine (n= 116), or placebo (n= 111) groups. All patients started treatment on 1 May, before the onset of the grass pollen season. The prophylactic effect of test drugs was assessed on their ability to delay the time to the first hay fever crisis of the season, which was defined by the occurrence of one of the following events: use of rescue medication, study withdrawal because of treatment failure, or total diary symptom score over 18. Active treatments prolonged the time to the first crisis by approximately 1 week (mizolastine 55 days, terfenadine 57 days) in comparison with placebo (50 days) (survival curve analysis: Logrank test, P= 0.01; Wilcoxon test, P= 0.03). Tolerability was satisfactory and comparable between groups. Thus, mizolastine can be safely used to delay and to treat symptoms of seasonal allergic rhinitis.