Mucoepidermoid carcinoma of the intrapancreatic common bile duct: immunohistochemical profile, prognosis, and review of the literature.
Mucoepidermoid carcinoma of the intrapancreatic common bile duct: immunohistochemical profile, prognosis, and review of the literature.
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DOI：
10.1155/2013/192458
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发表时间：
2013
影响因子：
0.6
通讯作者：
Garcia-Buitrago MT
中科院分区：
文献类型：
--
作者：
Moul AE;Bejarano PA;Casillas J;Levi JU;Garcia-Buitrago MT
摘要胆管黏液表皮样癌是一种罕见的肿瘤。在韩国文献中只有一例来自胆总管的黏液表皮样癌的报告。在这里，我们提出了第一个在英语文学。肿瘤发生在胰内（远端）胆总管在一个83岁的妇女谁提出了阻塞性黄疸和肝酶升高。肿瘤侵犯下方胰腺和胰周脂肪组织，并显示向胰外胆总管和胆囊管的pagetoid扩散。肿瘤呈恶性细胞巢，弥漫性CK 7和MUC 1阳性。基底细胞p63、CK 5/6阳性。管腔细胞用癌胚抗原、MUC 5和粘蛋白胺染色，CK 20呈局灶性阳性。在顶端管腔边缘有局灶性MUC 4染色。肿瘤细胞对MUC 2和HER 2-neu呈阴性。我们将讨论总胆管黏液表皮样癌的临床表现、诊断特征、免疫组化及预后。其特征与肝胆系统粘液表皮样癌、腺鳞癌及其他器官粘液表皮样癌作进一步比较。
Mucoepidermoid carcinoma of the bile duct is a rare entity. Only one mucoepidermoid carcinoma from the common bile duct has been reported in the Korean literature. Herein, we present the first in the English literature. The tumor arose in the intrapancreatic (distal) common bile duct in an 83-year-old woman who presented with obstructive jaundice and elevated liver enzymes. The tumor invaded the underlying pancreas and peripancreatic adipose tissue and showed pagetoid spread into the extrapancreatic common bile duct and cystic duct. The tumor exhibited nests of malignant cells with diffuse CK7 and MUC1 positivity. The basal cells were p63 and CK5/6 positive. The luminal cells were stained with carcinoembryonic antigen, MUC5, and mucicarmine and were focally positive for CK20. There was focal MUC4 staining on the apical luminal border. The neoplastic cells were negative for MUC2 and HER2-neu. We discuss the clinical presentation, diagnostic features, immunohistochemical profile, and prognosis of mucoepidermoid carcinoma of the common bile duct. The features of this neoplasm are further compared with mucoepidermoid carcinoma of the hepatobiliary system, adenosquamous carcinoma, and mucoepidermoid carcinoma of other organs.