Visualizing the laboratory mouse: capturing phenotype information
Visualizing the laboratory mouse: capturing phenotype information
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DOI：
10.1007/s10709-004-1435-7
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发表时间：
2004-09-01
期刊：
影响因子：
1.5
通讯作者：
Eppig, JT
中科院分区：
文献类型：
--
作者：
Strivens, M;Eppig, JT
通过突变计划开发无数新的表型等位基因的共同努力为生物医学界和支持这项工作所需的信息学基础设施提出了新的挑战。要处理和协调各种明显和细微特征的治疗、育种和顺序或纵向测试的大型项目，需要复杂的数据管理软件。此外，必须收集性状分析、遗传力测试以及动物的可获得性和状态，并将其传播给更广泛的社区。小鼠基因组数据库(MGD)将作为各种诱变计划的中心集成点，登记新的等位基因，提供加入识别符，并捕获表型描述。此外，MGD将为公众提供对所有等位基因的统一搜索，并链接到起源中心以获取详细的测试数据。
A concerted effort to develop myriad new phenotypic alleles through mutagenesis programs presents new challenges for the biomedical community and for the informatics infrastructure needed to support this work. To handle and co-ordinate large programs of treatment, breeding, and sequential or longitudinal testing for a variety of obvious and subtle traits requires sophisticated data management software. Further, trait analyses, heritability testing, and animal availability and status must be captured and disseminated to the wider community. The Mouse Genome Database (MGD) will serve as the central integration point for the various mutagenesis programs, registering new alleles, providing accession identifiers, and capturing phenotypic descriptions. In addition, MGD will provide public access to unified searches over all alleles with links to the centres of origin for detailed testing data.