The neurochemical mobile with non-linear interaction matrix: an exploratory computational model.
The neurochemical mobile with non-linear interaction matrix: an exploratory computational model.
复制标题
具有非线性相互作用矩阵的神经化学移动：探索性计算模型。
DOI：
10.1055/s-0033-1337920
复制
发表时间：
2013
影响因子：
4.3
通讯作者：
Voit,EO
中科院分区：
文献类型：
--
作者：
Qi,Z;Fieni,D;Tretter,F;Voit,EO
几年前，“神经化学移动的”被引入作为一种视觉工具，用于解释大脑中神经递质之间的不同平衡及其在精神疾病中的作用。在这里，我们补充了这个概念与非线性计算系统模型代表神经递质之间的直接和间接的相互作用，因为他们已经在“神经化学相互作用矩阵”中描述。该模型是在生化系统理论的框架内构建的，该理论有助于将数值上表征不良的系统映射到允许各种分析的数学和计算结构中。模拟显示了任何神经递质的短期和长期扰动如何通过整个系统迁移，从而影响移动的内的平衡。在短期改变的情况下，瞬态是特别感兴趣的，而长期变化揭示了持续改变的非稳态状态，在精神疾病和睡眠障碍中，这可能是由于不利因素的组合，由特定的遗传易感性，表观遗传效应，疾病或重复使用药物，如阿片类药物和安非他明。
Several years ago, the “neurochemical mobile” was introduced as a visual tool for explaining the different balances between neurotransmitters in the brain and their role in mental disorders. Here we complement this concept with a non-linear computational systems model representing the direct and indirect interactions between neurotransmitters, as they have been described in the “neurochemical interaction matrix.” The model is constructed within the framework of biochemical systems theory, which facilitates the mapping of numerically ill-characterized systems into a mathematical and computational construct that permits a variety of analyses. Simulations show how short- and long-term perturbations in any of the neurotransmitters migrate through the entire system, thereby affecting the balances within the mobile. In cases of short-term alterations, transients are of particular interest, whereas long-term changes shed light on persistently altered, allostatic states, which in mental diseases and sleep disorders could be due to a combination of unfavorable factors, resulting from a specific genetic predisposition, epigenetic effects, disease, or the repeated use of drugs, such as opioids and amphetamines.