Fat Replacement of Paraspinal Muscles with Aging in Healthy Adults
Fat Replacement of Paraspinal Muscles with Aging in Healthy Adults
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DOI：
10.1249/mss.0000000000001119
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发表时间：
2017-03-01
期刊：
影响因子：
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通讯作者：
Vissing, John
中科院分区：
文献类型：
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作者：
Dahlqvist, Julia R.;Vissing, Christoffer R.;Vissing, John
目的：本研究的目的是调查与年龄相关的变化，脂肪替代和横截面积（CSA）的颈，胸，腰椎旁肌肉与腿部肌肉在健康成人，并测试肌肉脂肪分数和生活方式因素之间的关联。方法：53名健康成人（24-76岁）。采用狄克逊磁共振成像技术测定CSA，并定量测定椎旁肌和腿部肌肉的脂肪含量。测试肌肉CSA和脂肪分数与年龄和肌肉力量的相关性。还测试了脂肪分数与性别，体重指数（BMI），体力活动和下背痛的关系。结果：椎旁和腿部脂肪分数与年龄直接相关（P < 0.0001）。在所有年龄段，椎旁肌的脂肪含量均高于腿部肌肉。随年龄增长，椎旁肌脂肪含量的增加高于腿部肌（P < 0.0001）。肌肉的CSA与年龄无关。伸膝肌力与脂肪含量相关（P < 0.05），臀肌、股肌、小腿前肌肌力与CSA相关（P < 0.05）。性别与腰段椎旁脂肪分数相关（P < 0.05），BMI与大腿脂肪分数相关（P < 0.001）。脂肪分数与体力活动或下背痛之间没有关联。结论：椎旁肌比下肢肌更易发生增龄性变化。此外，男性腰椎旁肌肉的脂肪分数明显较低，BMI与大腿脂肪分数呈正相关，但与椎旁脂肪分数无关。
Purpose: The aims of this study were to investigate the age-related changes in fatty replacement and cross-sectional area (CSA) of cervical, thoracic, and lumbar paraspinal muscles versus leg muscles in healthy adults and to test for association between muscle fat fraction and lifestyle factors. Methods: Fiftythree healthy adults (24-76 yr) were included. Dixon magnetic resonance imaging technique was used to determine CSA and to quantify the fat fraction of paraspinal and leg muscles. Muscle CSA and fat fractions were tested for association with age and muscle strength. The fat fractions were also tested for association with sex, body mass index (BMI), physical activity, and lower back pain. Results: Both paraspinal and leg fat fractions correlated directly with age (P < 0.0001). At all ages, fat fraction was higher in paraspinal than leg muscles. The age-related increase in fat fraction was higher in paraspinal muscles than leg muscles (P < 0.0001). The CSA of the muscles did not correlate with age. Knee extension strength correlated with fat fraction (P < 0.05), and the muscle strength of hip muscles, thigh muscles, and anterior calf muscles correlated with CSA (P < 0.05). Sex was associated with lumbar paraspinal fat fraction (P < 0.05) and BMI with thigh fat fraction (P < 0.001). There was no association between fat fraction and physical activity or lower back pain. Conclusion: The paraspinal muscles were more susceptible to age-related changes than leg muscles. Further, men had significantly lower fat fractions in lumbar paraspinal muscles, and BMI was positively associated with thigh, but not paraspinal, fat fraction.