Genome-wide approaches to understanding and improving complex traits in aquaculture species.
Genome-wide approaches to understanding and improving complex traits in aquaculture species.
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了解和改善水产养殖物种复杂性状的全基因组方法。
DOI：
10.1079/pavsnnr201712055
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Palaiokostas C
中科院分区：
文献类型：
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作者：
Palaiokostas C
核酸测序成本的快速下降和通量的提高为水产养殖遗传育种提供了许多机会。全基因组遗传标记数据现在可以很容易地以具有成本效益的方式生成，即使是对于没有广泛的基因组工具的物种。结果是，水产养殖物种的全基因组关联研究（GWAS）和基因组选择（GS）变得越来越常规。由于全球水产养殖产量中只有一小部分是通过选择性育种获得的，因此该行业具有巨大的潜力。GWAS和GS可以帮助实现这一潜力，在过去的5年里，已经看到了许多水产养殖物种的研究，主要集中在生长相关和抗病性状。目前的审查讨论了背景信息有关的方法，使用全基因组标记数据的GWAS和GS，并讨论了在商业化水产养殖育种遗传改良的实际实施经验教训。这些技术和技术的未来发展方向进行了讨论。
The rapid drop in cost and increase in throughput of nucleic acid sequencing has provided many opportunities for aquaculture genetics and breeding. Genome-wide genetic marker data can now be readily generated in a cost-effective manner, even for species without extensive prior genomic tools. The result is that genome-wide association studies (GWAS) and genomic selection (GS) in aquaculture species are becoming increasingly routine. With only a small percentage of global aquaculture production obtained through selective breeding, it holds tremendous potential for the industry. GWAS and GS can help realize this potential, and the last 5 years has seen numerous studies in aquaculture species focusing mainly on growth-related and disease resistance traits. The current review discusses background information relating to methods of using genome-wide marker data for GWAS and GS, and discusses lessons learned through their practical implementations in commercial aquaculture breeding for genetic improvement. Future directions for these techniques and technologies are discussed.