Post-translational regulation in plants employing a diverse set of polypeptide tags
Post-translational regulation in plants employing a diverse set of polypeptide tags
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DOI：
10.1042/bst0330393
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发表时间：
2005-04-01
影响因子：
3.9
通讯作者：
Vierstra, RD
中科院分区：
文献类型：
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作者：
Downes, B;Vierstra, RD
植物利用多肽作为翻译后修饰剂的概念正迅速成为操纵各种细胞过程的重要方法。最著名的是Ub（泛素），它作为26s蛋白酶体选择性降解蛋白质和内体运输的可重复使用的标签。基因组分析表明，仅Ub途径就占拟南芥蛋白质组的6%以上，其中数千种蛋白质是靶标。因此，这一途径影响了许多植物生物学。其他标签包括rub1（与Ub-1相关，也称为NEDD8）， SUMO（小ub样修饰剂），ATG-8（自噬-8）和ATG-12， UFM-1 （Ub-fold修饰剂-1）和HUB-1（与Ub-1同源）。初步研究表明，这些标签具有更有限的靶标集，并提供更专门的功能，包括转录调节，蛋白质定位，自噬转换和Ub的拮抗作用。基于其广泛的分布和普遍的功能，肽标签现在可以被认为是植物细胞调节的主要参与者。
The concept that plants exploit polypeptides as post-translational modifiers is rapidly emerging as an important method to manipulate various cellular processes. The best known is Ub (ubiquitin) that serves as reusable tag for selective protein degradation by the 26 S proteasome and for endosomal trafficking. Genomic analyses indicate that Ub pathway alone comprises over 6% of the Arabidopsis proteome with thousands of proteins being targets. Consequently, this pathway influences much of plant biology. others tags include RUB-1 (related to Ub-1; also known as NEDD8), SUMO (small Ub-like modifier), ATG-8 (autophagy-8) and ATG-12, UFM-1 (Ub-fold modifier-1) and HUB-1 (homology to Ub-1). Preliminary studies indicate that these tags have much more limited sets of targets and provide more specialized functions, including transcriptional regulation, protein localization, autophagic turnover and antagonizing the effects of Ub. On the basis of their widespread distribution and pervasive functions, peptide tags can now be considered as prime players in plant cell regulation.