Differential effects of ketamine and MK-801 on the induction of long-term potentiation.
Differential effects of ketamine and MK-801 on the induction of long-term potentiation.
复制标题
氯胺酮和 MK-801 对诱导长时程增强的不同作用。
DOI：
10.1097/00001756-199105000-00006
复制
发表时间：
1991
期刊：
影响因子：
1.7
通讯作者：
Thompson,RF
中科院分区：
文献类型：
--
作者：
Maren,S;Baudry,M;Thompson,RF
氯胺酮和MK-801是苯环利定（PCP）样n -甲基-d -天冬氨酸（NMDA）受体的非竞争性拮抗剂，可对NMDA受体偶联通道产生使用依赖性阻断。最近的研究表明，这些药物在体外与NMDA受体的结合特性是不同的。本研究比较了氯胺酮和MK-801对麻醉大鼠穿孔通路-颗粒细胞突触长期增强（LTP）的诱导作用。在生理盐水或MK-801治疗的动物中观察到LTP，但在氯胺酮治疗的动物中没有。这些结果表明氯胺酮和MK-801对LTP的诱导有不同的调节作用，我们认为这种差异调节可能与两种药物不同的结合特性有关。
Ketamine and MK-801 are phencyclidine (PCP)-like noncompetitive antagonists of the N-methyl-D-aspartate (NMDA) receptor that produce a use-dependent blockade of the NMDA receptor-coupled channel. Recent studies have suggested that the binding properties of these drugs to the NMDA receptor in-vitro are different. In the present study, the effects of ketamine and MK-801 on the induction of long-term potentiation (LTP) were compared at perforant path--granule cell synapses in anaesthetized rats. LTP was observed in animals treated with either saline or MK-801, but not in those treated with ketamine. These results reveal that ketamine and MK-801 differentially modulate the induction of LTP, and we propose that this differential modulation may be related to the different binding properties of the drugs.