A Biomimetic Approach to the Synthesis of the Core Structure of the Marine Sponge Terpene Halichonadin G
A Biomimetic Approach to the Synthesis of the Core Structure of the Marine Sponge Terpene Halichonadin G
复制标题
仿生海洋海绵萜烯G的核心结构合成方法
DOI：
10.1002/ejoc.201301206
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Toshiya Masuda and Yoshiyasu Ichikawa
中科院分区：
文献类型：
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作者：
Kenta Saitou;Ayumi Nishihori;Rika Mumura;Keiji Nakano;Toshiya Masuda and Yoshiyasu Ichikawa
本文提出了一条涉及糖酶和异腈氧化酶独特作用的海葵素G生物合成途径。这一假设在仿生方法中进行了测试，以合成这种海绵萜烯的核心结构单元，该方法依赖于关键的Ugi偶联反应和异氰化物到异氰酸酯的氧化转化。结果表明，利用仿生策略可以有效地构建出软海绵素G的核心结构。
A pathway for the biosynthesis of halichonadin G involving the unique action of ugiase and isocyanide oxidase is proposed. This hypothesis was tested in a biomimetic approach to the synthesis of the core structural unit of this marine sponge terpene, which relies on a key Ugi coupling reaction and an isocyanide‐to‐isocyanate oxidative transformation. The results of this effort demonstrate that the biomimetic strategy can be employed to construct the core structure of halichonadin G in an efficient manner.