Aquaporin 1 expression is associated with response to adjuvant chemotherapy in stage II and III colorectal cancer
Aquaporin 1 expression is associated with response to adjuvant chemotherapy in stage II and III colorectal cancer
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DOI：
10.3892/ol.2018.8170
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发表时间：
2018-05-01
期刊：
影响因子：
2.9
通讯作者：
Ishida, Hideyuki
中科院分区：
文献类型：
--
作者：
Imaizumi, Hideko;Ishibashi, Keiichiro;Ishida, Hideyuki
水通道蛋白1 （AQP1）作为一种水转运蛋白，在包括结直肠癌（CRC）在内的多种实体癌中与癌细胞的增殖、侵袭、转移和血管生成相关。本研究的重点是探讨AQP1表达在结直肠癌中的潜在临床应用，作为疾病复发和治疗结果的预后和预测性生物标志物。目前的研究调查了AQP1在268例0-IV期结直肠癌手术切除标本中的表达。112例（41.8%）患者AQP1表达阳性，且与左侧肿瘤显著相关(P
Aquaporin 1 (AQP1), which functions as a water transporter, is associated with cancer cell proliferation, invasion, metastasis and angiogenesis in numerous types of solid cancer, including colorectal cancer (CRC). The focus of the present study was to address the potential clinical use of AQP1 expression in CRC as a prognostic and predictive biomarker for disease recurrence and therapeutic outcomes. The current study investigated the expression of AQP1 in surgically resected specimens from 268 patients with stage 0-IV CRC. AQP1 expression was positive in 112 (41.8%) patients, and was significantly associated with left-sided tumors (P