Inhibitory effects of effective component in Zhimu on platelet aggregation in vitro and in vivo
Inhibitory effects of effective component in Zhimu on platelet aggregation in vitro and in vivo
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发表时间：
2005
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通讯作者：
Zhang Ai-lin
中科院分区：
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作者：
Zhang Ai-lin
目的研究知母有效成分（复方9714）对血小板聚集的影响。方法采用比浊法测定血小板聚集率。结果化合物9714代谢产物10 - 3、10 - 4、10 - 5和10 - 6 mol·L-1分别抑制ADP和胶原诱导的兔血小板聚集（P0. 05、P0. 01）。化合物9714 10、2 0和4 0 mg·kg-1 ig 5 ~ 7 d，可明显抑制ADP和胶原诱导的大鼠血小板聚集（P0.0 5，P0.0 1）。结论化合物9714代谢产物具有明显的抑制血小板聚集作用。
Aim To study the effects of effective component in Zhimu (compound 9714) on platelet aggregation. Methods Turbidimetry was used to measure platelet aggregation. Results Metabolite of compound 9714 10 -3,10 -4,10 -5 and 10 -6 mol·L -1 inhibited rabbit platelet aggregation induced by ADP and collagen in vitro, respectively( P0.05,P0.01). Compound 9714 10, 20 and 40 mg·kg -1 ig for 5 d to 7 d markedly inhibited platelet aggregation induced by ADP and collagen in rats( P0.05,P0.01). Conclusion Metabolite of compound 9714 could inhibit platelet aggregation evidently.