A 100% increase of 687 dopaminergic cells in the olfactory bulb may explain hyposmia in Parkinson's disease
A 100% increase of 687 dopaminergic cells in the olfactory bulb may explain hyposmia in Parkinson's disease
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DOI：
10.1002/mds.10713
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发表时间：
2004-06-01
影响因子：
8.6
通讯作者：
Hoogland, PV
中科院分区：
文献类型：
--
作者：
Huisman, E;Uylings, HBM;Hoogland, PV
嗅觉减退是帕金森病最常见的症状之一。它甚至可能发生在运动症状开始之前。为了确定是否嗅觉功能障碍，如运动症状，与多巴胺的损失，多巴胺能细胞的数量在帕金森病患者的嗅球进行了研究，使用酪氨酸羟化酶免疫组织化学。定量分析显示，帕金森病患者嗅球中酪氨酸羟化酶免疫反应阳性神经元的总数是年龄和性别匹配的对照组的两倍。由于多巴胺是已知的抑制嗅觉传递的嗅球，我们认为，增加多巴胺能神经元的嗅球是负责在帕金森病患者的嗅觉减退。嗅球中多巴胺的增加解释了为什么左旋多巴治疗不能改善嗅觉。(C)2004年，《运动障碍协会》。
Hyposmia is one of the most prevalent symptoms of Parkinson's disease. It may occur even before the motor symptoms start. To determine whether the olfactory dysfunctions, like the motor symptoms, are associated with a loss of dopamine, the number of dopaminergic cells in the olfactory bulb of Parkinson's disease patients was studied using tyrosine hydroxylase immunohistochemistry. The quantitative analysis reveals that the total number of tyrosine hydroxylase-immunoreactive neurons in the olfactory bulb is twice as high in Parkinson patients compared to age and gender-matched controls. Because dopamine is known to inhibit olfactory transmission in the olfactory glomeruli, we suggest that the increase of dopaminergic neurons in the olfactory bulb is responsible for the hyposmia in Parkinson patients. The increase of dopamine in the olfactory bulb explains why olfaction does not improve with levodopa therapy. (C) 2004 Movement Disorder Society.