CAM-DR: Mechanisms, Roles and Clinical Application in Tumors.
CAM-DR: Mechanisms, Roles and Clinical Application in Tumors.
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CAM-DR：在肿瘤中的机制、作用和临床应用
DOI：
10.3389/fcell.2021.698047
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发表时间：
2021
影响因子：
5.5
通讯作者：
Ju S
中科院分区：
文献类型：
--
作者：
Huang Y;Wang Y;Tang J;Qin S;Shen X;He S;Ju S
尽管各种治疗技术不断改进，肿瘤的总体预后有了明显改善，但中晚期恶性肿瘤仍不能完全治愈。细胞粘附介导的耐药（CAM-DR）限制了癌症治疗的成功，是临床上需要克服的巨大障碍。肿瘤细胞与细胞外基质（ECM）分子或邻近细胞之间的相互作用可能在启动与细胞增殖、结合其配体后的存活相关的细胞内信号传导途径中起重要作用。近年来的研究表明，这些粘附相关因子可能有助于肿瘤细胞在化疗后的存活，有利于耐药细胞的增殖和产生多种耐药机制。在这篇综述中，我们着重于这些相互作用的分子基础和参与增强癌细胞存活的主要信号转导途径。此外，还将讨论针对癌细胞与其环境之间的相互作用以增强药物反应或防止耐药性出现的疗法。
Despite the continuous improvement of various therapeutic techniques, the overall prognosis of tumors has been significantly improved, but malignant tumors in the middle and advanced stages still cannot be completely cured. It is now evident that cell adhesion-mediated resistance (CAM-DR) limits the success of cancer therapies and is a great obstacle to overcome in the clinic. The interactions between tumor cells and extracellular matrix (ECM) molecules or adjacent cells may play a significant role in initiating the intracellular signaling pathways that are associated with cell proliferation, survival upon binding to their ligands. Recent studies illustrate that these adhesion-related factors may contribute to the survival of cancer cells after chemotherapeutic therapy, advantageous to resistant cells to proliferate and develop multiple mechanisms of drug resistance. In this review, we focus on the molecular basis of these interactions and the main signal transduction pathways that are involved in the enhancement of the cancer cells’ survival. Furthermore, therapies targeting interactions between cancer cells and their environment to enhance drug response or prevent the emergence of drug resistance will also be discussed.
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影响因子：
4.3
作者：
Borsig L
通讯作者：
Borsig L
影响因子：
3.3
作者：
El Azreq MA;Naci D;Aoudjit F
通讯作者：
Aoudjit F
影响因子：
--
作者：
Di Marzo L;Desantis V;Solimando AG;Ruggieri S;Annese T;Nico B;Fumarulo R;Vacca A;Frassanito MA
通讯作者：
Frassanito MA
影响因子：
8
作者：
Billottet, C.;Grandage, V. L.;Khwaja, A.
通讯作者：
Khwaja, A.
影响因子：
20.3
作者：
Damiano, JS;Cress, AE;Dalton, WS
通讯作者：
Dalton, WS