High prevalence of markers of coronary heart disease among Greenland Inuit
High prevalence of markers of coronary heart disease among Greenland Inuit
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DOI：
10.1016/j.atherosclerosis.2007.01.008
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发表时间：
2008-02-01
期刊：
影响因子：
5.3
通讯作者：
Borch-Johnsen, Knut
中科院分区：
文献类型：
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作者：
Jorgensen, Marit Eika;Bjerregaard, Peter;Borch-Johnsen, Knut
目的：人们普遍认为因纽特人很少患冠心病，这可能是由于他们摄入了大量的omega-3脂肪酸。这方面的科学证据很薄弱，在某种程度上是基于不确定的死亡率统计数据。本研究的目的是评估格陵兰因纽特人冠心病标志物的患病率，并研究冠心病标志物与行为和生物学变量之间的关系。设计：我们研究了居住在格陵兰岛的1316名因纽特人的心绞痛（AP）、自我报告的心肌梗死（MI）、心电图定义的心肌梗死和缺血的患病率。血液测试辅以结构化访谈、人体测量和血压测量，参与者接受口服葡萄糖耐量测试。结果：症状性冠心病（AP，自述心肌梗死）的患病率男性为7.3%，女性为6.9%，男性和女性分别有12.2%和13.4%的缺血性心电图改变。冠心病（AP +自述心肌梗死+ ECG定义心肌梗死）的总体患病率男性为10.8%，女性为10.2%。在格陵兰岛西方化程度最低的地区，发病率最高。缺乏运动、受教育程度低、血脂异常、高血压和糖尿病与冠心病有关。结论：冠心病标志物的患病率与西方人群无明显差异。因纽特人是一个正在经历社会和健康迅速转变的人口，心血管危险因素的出现，有必要对这一人口的心血管流行病学进行批判性的重新思考。2007爱思唯尔爱尔兰有限公司版权所有。
Objective: It is a common notion that coronary heart disease (CHD) is rare among the Inuit, possibly due to a high intake of omega-3-fatty acids. The scientific evidence for this is weak and to some extent based on uncertain mortality statistic. The aim of this study was to assess the prevalence of markers of CHD among Greenland Inuit, and to study associations between markers of CHD and behavioral and biological variables.Design: We studied prevalence of angina pectoris (AP), self-reported myocardial infarction (MI), and ECG defined MI and ischaemia in a population survey among 1316 Inuit living in Greenland. Blood tests were supplemented by structured interviews, anthropometry, and measurements of blood pressure, and the participants received an oral glucose tolerance test.Results: The prevalence of symptomatic CHD (AP, self-reported MI) was 7.3% among men and 6.9% among women, and 12.2% and 13.4% of men and women had ischaemic ECG changes. The overall prevalence of CHD (AP + self-reported MI + ECG defined MI) was 10.8% in men and 10.2% in women. The highest prevalence was observed in the least westernized areas in Greenland. Physical inactivity, low education, dyslipidemia, hypertension and diabetes were associated with CHD.Conclusion: The prevalence of markers of CHD was not different from that in Western populations. The Inuit is a population undergoing rapid social and health transitions, with the emergence of cardiovascular risk factors, and there is a need for critical rethinking of cardiovascular epidemiology in this population. (c) 2007 Elsevier Ireland Ltd. All rights reserved.