Ambient UVB and melanoma risk in the United States: A case-control analysis
Ambient UVB and melanoma risk in the United States: A case-control analysis
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DOI：
10.1016/j.annepidem.2007.01.030
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发表时间：
2007-06-01
影响因子：
5.6
通讯作者：
Berwick, Marianne
中科院分区：
文献类型：
--
作者：
Lea, C. Suzanne;Scotto, Joseph A.;Berwick, Marianne
目的：暴露于紫外线b （UVB）辐射是人类皮肤恶性黑色素瘤的一个公认的危险因素。间断性和累积性中波紫外线暴露最常通过访谈问卷来估计。本研究使用地面测量仪器评估累积中波紫外线，以估计中波紫外线与黑色素瘤之间的关系。方法：以人群为基础，在1987年至1989年期间，对诊断时居住在康涅狄格州的黑色素瘤病例（n = 380）和频率匹配的对照组（n = 364）进行了访谈，内容包括娱乐和度假活动、防晒实践、职业和其他因素。使用居住史，从中波辐射的环境测量中得出终身中波辐射的回归估计，并根据间歇性暴露进行调整。结果：病例和对照组在生命的前15年接受了一生平均UVB的29%。儿童期和成年后期每年娱乐活动的天数与黑色素瘤风险增加有关。当估计间歇性暴露在UVB下的一生时，黑色素瘤的风险在第九十分位数达到了5.7倍的峰值。结论：散发性和慢性日晒在黑色素瘤发病中起一定作用。在不同程度的阳光照射下，应该鼓励皮肤保护措施，不仅在儿童时期，而且在整个成年时期。
Purpose: Exposure to ultraviolet-B (UVB) radiation is a well-established risk factor for human cutaneous malignant melanoma. Intermittent and cumulative exposures from UVB have been estimated most often by interview questionnaire. This study assessed cumulative UVB using a ground-based measurement instrument to estimate the association between UVB and melanoma.Methods: Population-based, incident cases of melanoma (n = 380) and frequency-matched controls (n = 364) residing in Connecticut at diagnosis were interviewed between 1987 and 1989 about recreational and vacation activities, sun-protection practices, occupation, and other factors. Using a residential history, regression estimates of lifetime UVB were derived from ambient measures of UVB, adjusted for intermittent exposure.Results: Cases and controls received 29% of lifetime mean UVB in the first 15 years of life. Number of days per year in recreational activity during childhood and late adulthood were associated with increased melanoma risk. When estimating lifetime UVB adjusted for intermittent exposure, melanoma risk peaked at a 5.7-fold increased risk in the ninth decile.Conclusion: Sporadic and chronic sun exposure play a role in melanoma etiology. Skin-protection practices should be encouraged across levels of sun intensity, not only in childhood but throughout adulthood.