Microvascular Changes in the Retina Correlate with MRI Markers in Patients with Early-Onset Dementia.
Microvascular Changes in the Retina Correlate with MRI Markers in Patients with Early-Onset Dementia.
复制标题
DOI：
10.3390/brainsci12101391
复制
发表时间：
2022-10-14
期刊：
影响因子：
3.3
通讯作者：
Zhang, Shuting
中科院分区：
文献类型：
--
作者：
Zhang, Ziyi;Liu, Peng;Kwapong, William Robert;Wu, Bo;Liu, Ming;Zhang, Shuting
关键词：
背景和目的：最近的报道表明，用光学相干断层扫描血管成像(OCTA)对痴呆患者的视网膜微血管进行成像的结果反映了痴呆期间发生的大脑微循环的变化。与对照组相比，痴呆症患者已显示出黄斑微血管损害，但对其与痴呆相关的放射视觉评分的相关性知之甚少。我们的目的是探讨早发性痴呆(EOD)患者视网膜微血管与放射学视力分级之间的关系。方法：采用扫源OCTA(SS-OCTA)对所有EOD患者的视网膜微血管进行成像。OCTA工具中的自动化软件分割并测量浅血管丛(SVC)、深血管丛(DVC)和中心凹无血管区(FAZ)的密度。对所有MR图像进行放射学视觉评分。结果：调整危险因素后，内侧颞叶萎缩评分与额叶面积显著相关(p=0.031)。EOD患者PWMH与上腔静脉压显著相关(p=0.032)，而DWMH与上腔静脉压(p=0.007)、下腔静脉压(p=0.018)和最大通气量(p=0.001)显著相关。讨论：在EOD患者中，FAZ的变化与MTA评分相关，而视网膜微血管与白质高信号相关。我们的报告提示，视网膜微血管的变化可能反映了EOD患者大脑皮质的变化。
Background and Aims: Recent reports suggest that results from imaging retinal microvascular changes with optical coherence tomography angiography (OCTA) in dementia patients reflect cerebral microcirculation changes that occur during dementia. Macula microvascular impairment has been shown in dementia patients compared to controls, but very little is known about its correlation with radiological visual rating scores associated with dementia. We aimed to explore the association between retinal microvasculature and radiological visual rating in early-onset dementia (EOD) patients. Methods: Swept-source OCTA (SS-OCTA) was used to image the retinal microvasculature of all EOD patients. Automated software in the OCTA tool segmented and measured the densities in the superficial vascular plexus (SVC) and deep vascular plexus (DVC) and foveal avascular zone (FAZ) areas. Radiological visual rating scores were evaluated on all MR images. Results: Medial temporal lobe atrophy (MTA) scores significantly correlated with FAZ area (p = 0.031) in EOD patients after adjusting for risk factors. PWMH correlated with SVC (p = 0.032) while DWMH significantly correlated with SVC (p = 0.007), DVC (p = 0.018) and FAZ (p = 0.001) in EOD patients. Discussion: FAZ changes correlated with MTA scores in EOD patients, while retinal microvasculature correlated with white matter hyperintensity. Our report suggests that microvascular changes in the retina may reflect cortical changes in the brain of EOD patients.
登录
查看更多内容
DOI：
10.1016/j.jalz.2011.03.005
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
McKhann GM;Knopman DS;Chertkow H;Hyman BT;Jack CR Jr;Kawas CH;Klunk WE;Koroshetz WJ;Manly JJ;Mayeux R;Mohs RC;Morris JC;Rossor MN;Scheltens P;Carrillo MC;Thies B;Weintraub S;Phelps CH
通讯作者：
Phelps CH
早期发作的痴呆症：诊断和病因考虑因素。
DOI：
10.1186/alzrt197
发表时间：
2013-07-31
期刊：
Alzheimer's research & therapy
影响因子：
--
作者：
Masellis M;Sherborn K;Neto P;Sadovnick DA;Hsiung GY;Black SE;Prasad S;Williams M;Gauthier S
通讯作者：
Gauthier S
影响因子：
--
作者：
Lin J;Wang D;Lan L;Fan Y
通讯作者：
Fan Y
影响因子：
120.7
作者：
Amidei, Claudio Barbiellini;Fayosse, Aurore;Singh-Manoux, Archana
通讯作者：
Singh-Manoux, Archana
影响因子：
9.9
作者：
Appleton, Jason P.;Woodhouse, Lisa J.;Wardlaw, Joanna M.
通讯作者：
Wardlaw, Joanna M.