Total synthesis of viridiofungin A
Total synthesis of viridiofungin A
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DOI：
10.1039/b500660k
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发表时间：
2005-01-01
影响因子：
4.9
通讯作者：
Hatakeyama, S
中科院分区：
文献类型：
--
作者：
Morokuma, K;Takahashi, K;Hatakeyama, S
首次采用手性缩水甘油酸与乙烯基溴化镁的区域和立体选择性开环以及柠檬酸中心和十六碳-15-烯-8-酮的交叉歧化反应，以天然形式合成了绿色木霉的氨基烷基柠檬酸酯类抗生素--病毒菌素A。
Viridiofungin A, a member of amino alkyl citrate antibiotics from Trichoderma viride, was enantioselectively synthesized in naturally occurring form for the first time, employing regio- and stereoselective opening of the chiral glycidate with vinylmagnesium bromide and alkene cross metathesis of the citric acid core and hexadec-15-en-8-one as key steps.