Expression of the mouse Fkh1/Mf1 and Mfh1 genes in late gestation embryos is restricted to mesoderm derivatives

Expression of the mouse Fkh1/Mf1 and Mfh1 genes in late gestation embryos is restricted to mesoderm derivatives
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DOI:
10.1016/s0925-4773(98)00039-2
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发表时间:
1998-04-01
影响因子:
2.6
通讯作者:
Kaestner, KH
Kaestner, KH
中科院分区:
生物学4区
文献类型:
--
作者:
Hiemisch, H;Monaghan, AP;Kaestner, KH

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我们比较了小鼠叉头同源基因1/中胚层/间充质叉头1 (Fkh1/Mf1)与高度相关的翼螺旋基因Mfh1在妊娠晚期小鼠胚胎中的表达模式。这两个基因的转录本都局限于中胚层的衍生物。go在头、肋、椎、骨的软骨原基均有表达。然而,在分析的几种结构中,Fkh1/Mf1信号在发育中的软骨内层比Mfh1信号低。(C) 1998爱思唯尔科学爱尔兰有限公司
We have compared the expression patterns of the mouse Forkhead homologue 1/ mesoderm/mesenchyme forkhead 1 (Fkh1/Mf1) gene with that of the highly related winged helix gene Mfh1 in late gestation mouse embryos. Transcripts for both genes are restricted to derivatives of the mesoderm. Go-expression was found in cartilage primordia of the head, ribs, vertebra and bones. However, in several structures analyzed, Fkh1/Mf1 signals are lower in the inner layers of the developing cartilage than those of Mfh1. (C) 1998 Elsevier Science Ireland Ltd.