Age is a major determinant for poor prognosis in patients with pilocytic astrocytoma: a SEER population study
Age is a major determinant for poor prognosis in patients with pilocytic astrocytoma: a SEER population study
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年龄是毛细胞型星形细胞瘤患者预后不良的主要决定因素：SEER 人群研究
DOI：
10.1007/s10238-022-00882-5
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发表时间：
2022
影响因子：
4.6
通讯作者：
Otani Yoshihiro
中科院分区：
文献类型：
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作者：
Tomita Yusuke;Hibler Elizabeth A.;Suruga Yasuki;Ishida Joji;Fujii Kentaro;Satomi Kaishi;Ichimura Koichi;Hirotsune Nobuyuki;Date Isao;Tanaka Yoshihiro;Otani Yoshihiro
毛细胞型星形细胞瘤（pilocytic astrocytoma，PAs）是中枢神经系统肿瘤，预后不一，危险因素尚不清楚.几乎没有证据表明年龄对PA死亡率的影响。因此，我们在美国对PA进行了彻底的表征。方法我们查询了2000年至2018年的监测、流行病学和最终结果（SEER）数据库，以提取PA的年龄调整发病率（AAIR）、年龄调整死亡率（AAMR）和生存数据。每项措施的年龄组比较因现有SEER数据而异。我们按两个年龄组（儿童，0-19岁;成人，20岁以上）和性别比较了AAIR和AAMR的趋势。累积发病率函数和精细灰色竞争风险模型应用于0-19，20-39，40-59，和60 +岁的年龄组。ResultsThis study includes 5211事件PA和462 PA特异性死亡2000年至2018年。AAIR和AAMR的趋势在2000年至2018年期间几乎保持不变。平均AAIRs在1-4岁年龄组有一个尖锐的高峰，而AAMR在80-84岁年龄组有一个渐进的高峰。年龄组，肿瘤位置，种族/民族与PA特异性死亡显着相关，而只有年龄与其他死因deaths.ConclusionsTrends在AAIRs和AAMRs是恒定的，无论年龄。老年人，特别是60岁以上的老年人，其死亡率高于年轻人。
BackgroundPilocytic astrocytomas (PAs) are central nervous system tumors with variable prognosis and poorly understood risk factors. Little evidence exists regarding the effect of age on mortality in PA. Therefore, we conducted a thorough characterization of PA in the US.MethodsWe queried the Surveillance, Epidemiology, and End Results (SEER) database between 2000 and 2018 to extract age-adjusted incidence rate (AAIR), age-adjusted mortality rate (AAMR), and survival data on PA. The age group comparisons for each measure varied depending on available SEER data. We compared trends in AAIR and AAMR by two age groups (children, 0–19 years; adults, 20 + years) and by sex. The cumulative incidence function and the Fine-Gray competing risk model were applied by 0–19, 20–39, 40–59, and 60 + years of age groups.ResultsThis study included 5211 incident PA and 462 PA-specific deaths between 2000 and 2018. Trends in AAIRs and AAMRs were almost constant between 2000 and 2018. Average AAIRs had a sharp peak in 1–4 years of age groups, whereas AAMRs had a gradual peak in 80–84 years of age groups. Age groups, tumor location, and race/ethnicity were significantly associated with PA-specific death, whereas only age was associated with other cause of deaths.ConclusionsTrends in AAIRs and AAMRs were constant regardless of age. PAs in older populations, especially over 60 years old, have higher incidence of death than those in younger populations.