Pharmacological modulation of stress reactivity dissociates general learning ability from the propensity for exploration
Pharmacological modulation of stress reactivity dissociates general learning ability from the propensity for exploration
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DOI：
10.1037/0735-7044.121.5.949
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发表时间：
2007-10-01
影响因子：
1.9
通讯作者：
Matzel, Louis D.
中科院分区：
文献类型：
--
作者：
Grossman, Henya C.;Hale, Gregory;Matzel, Louis D.
此前有报道称，一般学习能力（GLA）与个体远交小鼠的探索倾向呈正相关。这一发现表明应激反应性的变化可能会调节 GLA，从而调节 GLA 与探索倾向的关系。在这里，作者通过评估抗焦虑药氯二氮卓（CDP；10 mg/kg）对受试者在一系列不同学习任务中的表现以及探索行为和压力反应性的影响，研究了压力反应性在调节这种关系中的潜在作用。经过 CDP 治疗的小鼠表现出应激诱导的皮质酮水平和对轻度应激源的行为反应性的降低，以及相应的探索能力的增加。然而，CDP 治疗的小鼠并没有表现出任何学习任务的促进，并且表达的 GLA 与对照组相当。结果表明，虽然应激反应性的降低促进了探索，但这并没有转化为 GLA 的上调，这表明 GLA 和探索之间的关系不是由应激反应性介导的。作者提出，GLA 的变化反映了个体寻求新奇事物的倾向，而探索则反映了压力反应性和新奇寻求，后者可能是探索与 GLA 之间关系的基础。
It has previously been reported that general learning ability (GLA) correlates positively with exploratory tendencies in individual outbred mice. This finding suggests the possibility that variations in stress reactivity modulate GLA and thus its relationship to exploratory tendencies. Here, the authors investigated the potential role of stress reactivity in regulating this relationship by assessing the effects of the anxiolytic chlorodiazepoxide (CDP; 10 mg/kg) on subjects' performance in a battery of diverse learning tasks as well as exploratory behaviors and stress reactivity. CDP-treated mice exhibited reductions in stress-induced corticosterone levels and behavioral reactivity to mild stressors and a corresponding increase in exploration. However, CDP-treated mice did not exhibit facilitated acquisition of any of the learning tasks and expressed GLA comparable to controls. Results indicate that although reduced stress reactivity promotes exploration, this does not translate into an up-regulation of GLA, suggesting that the relationship between GLA and exploration is not mediated by stress reactivity. The authors propose that variations in GLA reflect individuals' propensity for novelty seeking, whereas exploration reflects both stress reactivity and novelty seeking, the latter of which may underlie the relationship between exploration and GLA.