LEUCOENCEPHALOPATHY AFTER INHALING "HEROIN" PYROLYSATE
LEUCOENCEPHALOPATHY AFTER INHALING "HEROIN" PYROLYSATE
复制标题
DOI：
10.1016/s0140-6736(82)90101-5
复制
发表时间：
1982-12
期刊：
影响因子：
--
通讯作者：
E. Wolters;F. Stam;R. Lousberg;G. Wijngaarden;H. Rengelink;M. Schipper;B. Verbeeten
中科院分区：
文献类型：
--
作者：
E. Wolters;F. Stam;R. Lousberg;G. Wijngaarden;H. Rengelink;M. Schipper;B. Verbeeten
描述了 47 名患有海绵状白质脑病的患者，但除了肺部肺泡巨噬细胞出现棕色色素沉着外，没有其他一致的异常。已有11名患者死亡。流行病学研究表明，吸入有毒海洛因蒸气（热解物）是导致该病的原因。海洛因主要在荷兰阿姆斯特丹的黑市上出售。收集了170多个可疑海洛因样本，用于分析可能的有毒因素。尽管存在疑问，但没有一个样本与观察到的疾病有明确的相关性。化学、毒理学和组织病理学研究迄今尚未揭示有毒因子的性质，但已排除几种已知可引起类似白质脑病的神经毒性物质。这似乎是未知致病因素潜在毒性的第一个表现。
47 patients with spongiform leucoencephalopathy but no other consistent abnormalities, except brown pigmentation of the alveolar macrophages in the lungs, are described. 11 patients have died. Epidemiological studies indicate as the cause of the illness the inhalatory use of poisoned heroin vapours (pyrolysate). The heroin is primarily sold on the black market in Amsterdam, The Netherlands. Over 170 suspect heroin samples were collected for analysis of the possible poisonous factor. Although suspect, none of the samples could be unambiguously related to the observed illness. Chemical, toxicological, and histopathological investigations have not so far revealed the nature of the poisonous factor, but several neurotoxic agents that are known to cause comparable leucoencephalopathies have been ruled out. This appears to be the first manifestation of the poisonous potential of the unknown causative factor.