High incidence of secondary brain tumours after radiotherapy and antimetabolites
High incidence of secondary brain tumours after radiotherapy and antimetabolites
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DOI：
10.1016/s0140-6736(98)11079-6
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发表时间：
1999-07-03
期刊：
影响因子：
168.9
通讯作者：
Pui, CH
中科院分区：
文献类型：
--
作者：
Relling, MV;Rubnitz, JE;Pui, CH
背景脑肿瘤在儿童急性淋巴细胞性白血病颅脑放疗后的幸存者中很少发生。在我们的白血病治疗方案之一的全面治疗研究XII中，在登记的儿童中发现了异常高的脑瘤发生率，促使我们确定了这种并发症的潜在原因。方法我们评估了接受预防性颅脑放疗的所有52名儿童的临床、生物学和药代动力学特征。我们比较了不同亚组之间的脑肿瘤累积发病率，并与先前研究中接受放射治疗的421名儿童的累积发病率进行了比较。结果发现，接受放射治疗的儿童中的脑肿瘤发生率(6/52，12.8%[SE5.0])高于同一研究中未接受放射治疗的患者(未接受放射治疗的患者；p=0.0008)，以及包括头颅放射治疗在内的其他方案(P<0.05)。
Background Brain tumours rarely occur in survivors of childhood acute lymphoblastic leukaemia after cranial radiotherapy. An unusually high frequency of brain tumours seen among children enrolled in one of our leukaemia treatment protocols, Total Therapy Study XII, prompted us to identify the potential causes of this complication.Methods We assessed clinical, biological, and pharmacokinetic features in all 52 children who received prophylactic cranial radiotherapy. We compared the cumulative incidence of brain tumours between subgroups, and with that of 421 children who received radiotherapy in previous studies.Findings The incidence of brain tumours among irradiated children (six of 52, 12.8% [SE 5.0]) was high compared with patients in the same study who did not receive radiotherapy (none of 101; p=0.0008) and with other protocols that included cranial radiotherapy (p