Voxel based comparison of glucose metabolism in the differential diagnosis of the multiple system atrophy using statistical parametric mapping
Voxel based comparison of glucose metabolism in the differential diagnosis of the multiple system atrophy using statistical parametric mapping
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DOI：
10.1016/j.neures.2005.03.010
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发表时间：
2005-07-01
影响因子：
2.9
通讯作者：
Choe, B
中科院分区：
文献类型：
--
作者：
Juh, R;Pae, CU;Choe, B
目的：特发性帕金森病（IPD）和多系统萎缩（NISA）的鉴别诊断是困难的，因为它们有共同的体征和症状。这种F-18-2-氟-2-脱氧葡萄糖的目的是应用正电子发射断层扫描（PET）技术，通过统计参数图（SPM）和图像配准，比较MSA和IPD患者局部脑葡萄糖代谢的变化。F-18-MSA和IPD患者的FDG PET图像通过SPNI和图像配准进行评估，以确定可能用于治疗的代谢模式A。区分这两个群体。结果：与正常对照组相比，11例MSA患者、8例IPD患者的前额叶、侧额叶、顶颞叶皮质、扣带回和尾状核区的葡萄糖代谢明显降低（P < 0.01）。
Objective: A differential diagnosis of idiopathic parkinsonian disease (IPD) and multiple system atrophy (NISA) is difficult due to their A common signs and symptoms. The aim of this F-18-2-fluoro-2 deoxyglucose (F-18-FDG) positron emission tomography (PET) study was to A compare the regional cerebral glucose metabolism in MSA with that in IPD by statistical parametric mapping (SPM) and image registration.Methods: The F-18-FDG PET images of MSA and IPD patients were assessed by SPNI and image registration to determine metabolic patterns A that may be useful in differentiating between the two groups. Eleven patients with MSA, eight patients with IPD and 22 healthy controls participated in the study.Results: The IPD patients were found to have a significant glucose hypometabolism in comparison with the healthy controls in the prefrontal, lateral frontal, and parietotemporal cortices, and the cingulate and caudate areas (p