ANALGESIA OR HYPERALGESIA FOLLOWING STRESS CORRELATES WITH EMOTIONAL BEHAVIOR IN RATS
ANALGESIA OR HYPERALGESIA FOLLOWING STRESS CORRELATES WITH EMOTIONAL BEHAVIOR IN RATS
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DOI：
10.1016/0304-3959(88)90046-2
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发表时间：
1988-03-01
期刊：
影响因子：
7.4
通讯作者：
JORUM, E
中科院分区：
文献类型：
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作者：
JORUM, E
暴露于各种有害和非有害应激源后的镇痛被充分记录，并且通常被称为应激诱导的镇痛。应激后的痛觉过敏也有报道。本研究表明，一个温和的应激（15分钟的振动）产生增加的甩尾laftering（TFL）在一些大鼠，但减少laftering在其他大鼠。个体受试者的结果在随后的会议中重现：大鼠在第1天显示TFL增加，在第2天响应TFL增加。在第1天显示TFL降低的大鼠在第2天响应TFL降低。无论发生什么样的反应，镇痛或痛觉过敏，这与动物在应激过程中的行为有关。安静的大鼠产生镇痛，而兴奋的大鼠产生痛觉过敏。各种引起运动过度反应的周围神经刺激程序也导致痛阈降低。本研究的结果显示疼痛机制的行为调制。
Analgesia following exposure to a variety of noxious and non-noxious stressors is well documented and is commonly referred to as stress-induced analgesia. Hyperalgesia following stress has also been reported. The present study shows that a mild stressor (15 min of vibration) produced increased tail-flick latencies (TFL) in some rats, but decreased latencies in other rats. The results of the individual subjects were reproduced in a later session: the rats showing increased TFL on day 1, responded with increased TFL on day 2. Rats showing decreased TFL on day 1 responded with decreased TFL on day 2. Whichever reaction occurred, analgesia or hyperalgesia, this correlated with the animal''s behavior during the stress procedure. Analgesia was produced in quiet rats and hyperalgesia in hyperemotional ones. Various peripheral nerve stimulation procedures producing hyperemotional reaction also resulted in lowering of the pain threshold. The results of the present study show behavioral modulation of pain mechanisms.