Characterization of a novel coronavirus associated with severe acute respiratory syndrome
Characterization of a novel coronavirus associated with severe acute respiratory syndrome
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DOI：
10.1126/science.1085952
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发表时间：
2003-05-30
期刊：
影响因子：
56.9
通讯作者：
Bellini, WJ
中科院分区：
文献类型：
--
作者：
Rota, PA;Oberste, MS;Bellini, WJ
2003年3月，一种新型冠状病毒（SARS-CoV）被发现与严重急性呼吸系统综合征（SARS）病例有关。SARS-CoV全基因组的序列测定，并在本报告中提出的病毒基因组的初步表征。SARS-CoV的基因组长度为29,727个核苷酸，有11个开放阅读框，其基因组组织与其他冠状病毒相似。系统发育分析和序列比较表明，SARS-CoV与任何先前表征的冠状病毒都没有密切关系。
In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratory syndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closely related to any of the previously characterized coronaviruses.