Proliferative responses to recall antigens are associated with pregnancy outcome in women with a history of recurrent spontaneous abortion.
Proliferative responses to recall antigens are associated with pregnancy outcome in women with a history of recurrent spontaneous abortion.
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对回忆抗原的增殖反应与有反复自然流产史的妇女的妊娠结局相关。
DOI：
10.1172/jci119652
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Hill,JA
中科院分区：
文献类型：
--
作者：
Bermas,BL;Hill,JA
母体对胎儿同种异体移植物的耐受性表明妊娠期发生了免疫调节。因此，复发性自然流产（RSA）可能代表维持妊娠的免疫变化失败。我们假设，育龄妇女，而不是RSA妇女可能会失去他们的免疫反应，回忆抗原怀孕时。这种现象在免疫抑制的移植受者中已经观察到，并且与移植物存活有关。因此，我们评估了四组妇女对回忆抗原的增殖反应：第1组，无流产史且至少有一次健康妊娠的非妊娠生育妇女，n = 13;第2组，有三次或三次以上自然流产史的非妊娠妇女，n = 28;第3组，孕6 ~ 9周无流产史的健康孕妇，n = 15;第4组，妊娠6 ~ 9周，有RSA病史的孕妇，n = 22。前瞻性地确定外周血白细胞对回忆抗原流感和破伤风、同种异体抗原和植物血凝素的应答。对回忆抗原的阳性反应（刺激指数> 3）（对流感或破伤风的反应被认为是阳性）如下：第1组（非妊娠生育妇女），11/13（85%）;第2组（非妊娠RSA妇女），24/28（86%）;第3组（妊娠生育妇女），4/15（27%）（P
Maternal tolerance of the fetal hemiallograft suggests that immunomodulation occurs during gestation. Therefore, recurrent spontaneous abortion (RSA) may represent a failure of the immune changes that maintain pregnancy. We hypothesized that fertile women but not women with RSA may lose their immune responses to recall antigens when pregnant. This phenomenon has been seen in immunosuppressed transplant recipients and is associated with graft survival. Therefore, we evaluated proliferative responses to recall antigens in four groups of women: group 1, nonpregnant fertile women with no history of pregnancy loss and at least one prior healthy pregnancy, n = 13; group 2, nonpregnant women with a history of three or more spontaneous abortions, n = 28; group 3, healthy pregnant women between 6 and 9 wk of gestation without a history of prior pregnancy loss, n = 15; and group 4, pregnant women between 6 and 9 wk of gestation, with a history of RSA, n = 22. Proliferative responses of peripheral blood leukocytes to the recall antigens influenza and tetanus, alloantigens, and phytohemagglutinin were determined prospectively. Positive responses (stimulation index > 3) to recall antigens (a response to either influenza or tetanus was considered positive) were as follows: group 1 (nonpregnant fertile women), 11/13 (85%); group 2 (nonpregnant RSA women), 24/28 (86%); group 3 (pregnant fertile women), 4/15 (27%) (P