AKT and its related molecular feature in aged mice skin.
AKT and its related molecular feature in aged mice skin.
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老年小鼠皮肤AKT及其相关分子特征
DOI：
10.1371/journal.pone.0178969
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Wu Y
中科院分区：
文献类型：
--
作者：
Chen H;Wang X;Han J;Fan Z;Sadia S;Zhang R;Guo Y;Jiang Y;Wu Y
以往的研究表明，Akt信号促进组织再生，在衰老组织中发现Akt活性降低。然而，本研究发现，Akt在小鼠皮肤中的表达和激活水平随着年龄的增长而增加。此外，Pten、p16、p21和P53的表达水平也随着年龄的增长而升高。免疫荧光分析显示，在表皮细胞中也发现了Akt的磷酸化(伴随着NF-κB的激活水平升高)。体内抑制AKT活性会导致NF-κB活性降低。我们的结果提示，AKT/NF-κB的增加是皮肤衰老的重要介质，它可以增加细胞转化的敏感性。
Previous studies suggest that Akt signaling promotes tissue regeneration and decreased Akt activities are found in aged tissues. However, this study finds that the expression and activation levels of Akt in the mice skin increased with age. Additionally, the expression levels of Pten, p16, p21 and p53 also elevated with increased age. Immuno-fluorescence analysis showed that Akt phosphorylation found in the epidermal cells (with increased levels of NF-κB activation) were also found. In vivo inhibition of AKT activity result in reduced NF-κB activation. Our results suggest that increasing Akt/ NF-κB is a crucial mediator of skin aging, which can increase the susceptibility of cell transformation.