Haemophilus influenzae type b disease. Incidence in a day-care center.
Haemophilus influenzae type b disease. Incidence in a day-care center.
复制标题
b 型流感嗜血杆菌疾病。
DOI：
10.1001/jama.238.7.604
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
James C. Parke
中科院分区：
文献类型：
--
作者：
Charles M. Ginsburg;George H. McCracken;Sharon Rae;James C. Parke
在一家日托中心的48名婴儿中，有7名在14个月期间观察到b型流感嗜血杆菌(HIB)疾病。监测研究表明，28名(58%)婴儿鼻咽培养HIB阳性；4名婴儿HIB定植9至12个月。预防三水氨苄西林不能降低HIB携带率。其中34名儿童接种了b型流感嗜血杆菌多糖疫苗。免疫前获得的血清在所有婴儿中均可检测到抗体。在接种疫苗后，只有9名婴儿(26%)的血清HIB抗体效价上升了一倍或更多。抗体应答与年龄、免疫前抗体浓度和HIB携带者状态无关。一名婴儿在接种多糖疫苗四个月后出现HIB脑膜炎。这次暴发强调，HIB在封闭的年幼易感婴儿人群中具有高度传染性。
Haemophilus influenzae type b (HIB) disease was observed during a 14-month period in seven of 48 infants attending a day-care center. Surveillance studies showed that 28 (58%) infants had positive nasopharyngeal cultures for HIB; four infants were colonized with HIB for nine to 12 months. Ampicillin trihydrate prophylaxis failed to reduce the HIB carrier rate. Haemophilus influenzae type b polysaccharide vaccine was administered to 34 of the children. Sera obtained prior to immunization showed detectable antibody in all infants. Only nine (26%) infants had twofold or greater rises in serum HIB antibody titers after vaccination. Antibody response was independent of age, preimmunization antibody concentration, and HIB carrier status. In one infant, HIB meningitis developed four months after she received polysaccharide vaccine. This outbreak emphasizes that HIB is highly contagious in closed populations of young, susceptible infants.