SUPPRESSION OF THE RENIN-ANGIOTENSIN SYSTEM BY INTRAVENOUS DIGOXIN IN CHRONIC CONGESTIVE HEART-FAILURE
SUPPRESSION OF THE RENIN-ANGIOTENSIN SYSTEM BY INTRAVENOUS DIGOXIN IN CHRONIC CONGESTIVE HEART-FAILURE
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DOI：
10.1016/0002-9343(83)90346-7
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发表时间：
1983-01-01
影响因子：
5.9
通讯作者：
CODY, RJ
中科院分区：
文献类型：
--
作者：
COVIT, AB;SCHAER, GL;CODY, RJ
洋地黄制剂在治疗慢性充血性心力衰竭方面的益处可能不一致。一种解释可能是对血管收缩激素的不同影响，因为地高辛抑制了正常人和高血压患者的血浆肾素活性。观察了6例代偿性重度慢性充血性心力衰竭患者短期应用地高辛对血浆肾素活性和血浆醛固酮的影响。地高辛(0.50 mg)静脉注射。导致血浆肾素活性从4.3。+-降低。0.9至2.0。+-每小时0.9 ng/ml，血浆醛固酮34.+-。16至14。+-。6 ng/dl(P<；0.05)。最大反应出现在给药后3h，7h恢复到基线水平。要评估洋地黄在慢性心力衰竭中的作用，需要考虑其对血管紧张素介导的血管收缩和醛固酮介导的Na+滞留的直接或间接影响，以及其他神经激素收缩血管的机制。
Digitalis preparations may be of inconsistent benefit in the treatment of chronic congestive heart failure. One explanation may be a varying effect on vasoconstrictor hormones, as digoxin suppresses plasma renin activity in normal and hypertensive persons. The effect of short-term digoxin administration on plasma renin activity and plasma aldosterone in six patients with compensated, severe, chronic congestive heart failure was evaluated. Digoxin (0.50 mg) i.v. resulted in a reduction of plasma renin activity from 4.3 .+-. 0.9 to 2.0 .+-. 0.9 ng/ml per h and plasma aldosterone from 34 .+-. 16 to 14 .+-. 6 ng/dl (both P < 0.05). Maximal response occurred at 3 h after administration, with return to baseline by 7 h. Evaluation of the role of digitalis in chronic heart failure requires consideration of its direct or indirect effect on angiotensin-mediated vasoconstriction and aldosterone-mediated Na+ retention, as well as other neurohormonal mechanisms of vasoconstriction.