Successful Treatment of Transient Acantholytic Dermatosis with Systemic Steroids
Successful Treatment of Transient Acantholytic Dermatosis with Systemic Steroids
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全身类固醇成功治疗暂时性棘层松解性皮肤病
DOI：
10.1111/j.1346-8138.1998.tb02437.x
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Z. Károlyi
中科院分区：
文献类型：
--
作者：
N. Erős;A. Kovács;Z. Károlyi
一名60岁男性患者，在其胸部、腹部、背部、臀部以及上肢和下肢近端部位的充血基底上出现2-5 mm大小的充血、瘙痒性丘疹、囊泡、糜烂和结痂。直接和间接免疫荧光试验均为阴性。组织学检查显示表皮广泛棘层松解，表现为以下形式：寻常型天疱疮样基底上棘层松解、Darier样棘层松解性角化不良伴发隆突、Hailey-Hailey样基底上裂和落叶型天疱疮样浅表棘层松解伴海绵状增生。使用全身类固醇，局部干燥和上皮再生治疗，患者治愈。完成类固醇治疗后的第一个月、第四个月和第十三个月，他的症状消失了。
A sixty‐year‐old man, developed 2–5 mm sized, hyperemic, itchy papules, vesicles, erosions and crusts on hyperemic base on his chest, abdomen, back, gluteal region, and proximal sites of his upper and lower extremities. The direct and indirect immunoflurescence tests were negative. Histology revealed extensive acantholysis in the epidermis in the following forms: pemphigus vulgaris‐like suprabasal acantholysis, Darier‐like acantholytic dyskeratosis with corps ronds, Hailey‐Hailey‐like suprabasal clefts, and pemphigus foliaceus‐like superficial acantholysis with spongiosis. Using systemic steroids, topical drying, and reepithelising therapy, the patient was cured. He was symptom‐free the first, fourth, and thirteenth months after finishing steroid therapy.