Anti-inflammatory and immuno suppressive compounds from Tripterygium wilfordii
Anti-inflammatory and immuno suppressive compounds from Tripterygium wilfordii
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DOI：
10.1016/j.phytochem.2007.02.021
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发表时间：
2007-04-01
期刊：
影响因子：
3.8
通讯作者：
Raskin, Ilya
中科院分区：
文献类型：
--
作者：
Ma, Jun;Dey, Moul;Raskin, Ilya
雷公藤提取物。对在类风湿性关节炎的人类临床试验中显示抗炎和免疫抑制活性的化合物（TwHF）进行活性指导的分级分离和生物活性物质的光谱表征。四氢呋喃木脂素、雷公藤醇（1）和八种已知化合物均能抑制促炎基因表达。提取物的大部分药理活性可归因于雷公藤内酯醇，其最丰富的活性成分，雷公藤内酯醇也有一定的贡献。(c)2007爱思唯尔有限公司版权所有。
The extract of Tripterygium wilfordii Hook F. (TwHF), which showed anti-infiammatory and immunosuppressive activities in human clinical trials for rheumatoid arthritis, was subjected to the activity-guided fractionation and spectroscopic characterization of bioactives. A tetrahydrofuran lignan, tripterygiol (1), and eight known compounds, all capable of suppressing pro-inflammatory gene expression were identified. Most of the pharmacological activity of the extract can be attributed to triptolide, its most abundant and active component, with some contribution from tripdiolide. (c) 2007 Elsevier Ltd. All rights reserved.