Explaining longevity of different animals: is membrane fatty acid composition the missing link?
Explaining longevity of different animals: is membrane fatty acid composition the missing link?
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DOI：
10.1007/s11357-008-9055-2
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发表时间：
2008-09-01
期刊：
影响因子：
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通讯作者：
Hulbert, A. J.
中科院分区：
文献类型：
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作者：
Hulbert, A. J.
饱和脂肪酸和单不饱和脂肪酸对过氧化损伤有很强的抵抗力，而多不饱和脂肪酸越多，就越容易受到过氧化的影响。此外，脂质过氧化的产物可以氧化损伤其他重要分子。膜脂肪酸组成与哺乳动物和鸟类的最大寿命有关。与寿命较短的类似大小的哺乳动物相比，寿命特别长的哺乳动物和鸟类具有更强的抗过氧化膜组成。在物种内，也有延长寿命与抗过氧化膜组成有关的情况。例如，热量限制与更耐过氧化的膜组成有关；长寿的蜂王比寿命较短的工蜂有更多的抗氧化膜。在人类中，与对照组相比，90岁老人的后代具有抗过氧化的红细胞膜组成。膜脂肪酸组成是一个鲜为人知但重要的关系到动物的衰老速度和它们的寿命的决定。
Saturated and monounsaturated fatty acids are very resistant to peroxidative damage, while the more polyunsaturated a fatty acid, the more susceptible it is to peroxidation. Furthermore, the products of lipid peroxidation can oxidatively damage other important molecules. Membrane fatty acid composition is correlated with the maximum lifespans of mammals and birds. Exceptionally long-living mammal species and birds have a more peroxidation-resistant membrane composition compared to shorter-living similar-sized mammals. Within species, there are also situations in which extended longevity is associated with peroxidation-resistant membrane composition. For example, caloric restriction is associated more peroxidation-resistant membrane composition; long-living queens have more peroxidation-resistant membranes than shorter-living worker honeybees. In humans, the offspring of nonagenarians have peroxidation-resistant erythrocyte membrane composition compared to controls. Membrane fatty acid composition is a little appreciated but important correlate of the rate of aging of animals and the determination of their longevity.