DIFFUSION-WEIGHTED MR IMAGING OF ANISOTROPIC WATER DIFFUSION IN CAT CENTRAL-NERVOUS-SYSTEM
DIFFUSION-WEIGHTED MR IMAGING OF ANISOTROPIC WATER DIFFUSION IN CAT CENTRAL-NERVOUS-SYSTEM
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DOI：
10.1148/radiology.176.2.2367658
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发表时间：
1990-08-01
期刊：
影响因子：
19.7
通讯作者：
NORMAN, D
中科院分区：
文献类型：
--
作者：
MOSELEY, ME;COHEN, Y;NORMAN, D
使用扩散加权磁共振 (MR) 成像检查猫脑和脊柱中颅内水的扩散行为，其中扩散敏化梯度的方向在磁体的 x、y 和 z 轴之间变化。在非常高的扩散敏化梯度强度下，在皮质或皮质下（基底神经节）灰质中没有发现各向同性水扩散的明确证据。在大脑的皮质和深层白质以及脊髓的白质中观察到信号强度明显依赖或方向。与垂直排列相比，当白质束与扩散敏化梯度的相对方向平行时，观察到更大的信号衰减（更快的扩散）。在所有轴向、矢状和冠状视图中获得的死前和死后立即图像上都可以看到这些影响。这种 MR 成像技术的潜在应用包括对大脑和脊髓中白质的立体特异性评估以及脱髓鞘和髓鞘形成障碍疾病的表征。
The diffusion behavior of intracranial water in the cat brain and spine was examined with the use of diffusion-weighted magnetic resonance (MR) imaging, is which the direction of the diffusion-sensitizing gradient was varied between the x, y, and z axes of the magnet. At very high diffusion-sensitizing gradient strengths, no clear evidence of an isotropic water diffusion was found in either cortical or subcortical (basal ganglia) gray matter. Signal intensities clearly dependent or orientation were observed in the cortical and deep white matter of the brain and in the white matter of the spinal cord. Greater signal attenuation (faster diffusion) was observed when the relative orientation of white matter tracts to the diffusion-sensitizing gradient was parallel as compared to that obtained with a perpendicular alignment. These effects were seen on both premortem and immediate postmortem images obtained in all axial, sagittal, and coronal views. Potential applications of this MR imaging technique include the stereospecific evaluation of white matter in the brain and spinal cord and in the characterization of demyelinating and dysmyelinating diseases.