Cognitive functioning of long-term heavy cannabis users seeking treatment
Cognitive functioning of long-term heavy cannabis users seeking treatment
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DOI：
10.1001/jama.287.9.1123
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发表时间：
2002-03-06
影响因子：
120.7
通讯作者：
Vendetti, J
中科院分区：
文献类型：
--
作者：
Solowij, N;Stephens, RS;Vendetti, J
背景认知障碍与长期大麻使用有关，但有助于损害的使用参数以及认知功能障碍的性质和持久性仍然不确定。目的研究大麻使用持续时间对寻求大麻依赖治疗的用户中认知功能特定区域的影响。设计，设置，和参与者在美国进行的多地点回顾性横断面神经心理学研究（西雅图，华盛顿州;法明顿，康涅狄格州;迈阿密，弗拉州）在1997年至2000年期间，在102名几乎每天吸食大麻的人中，（51名长期使用者：平均使用23.9年; 51名短期使用者：平均10.2年的使用）与33名非使用者对照组进行比较。主要结果测量来自9项标准神经心理学测试的测量，这些测试评估了注意力，记忆力，和执行功能，并在进入治疗计划和中位数17小时abstines.Results后进行管理，长期大麻用户的表现显着不如短期用户和控制测试的记忆和注意力。在雷伊听觉语言学习测试中，长期使用者回忆起的单词明显少于短期使用者（P=.001）或对照组（P=.005）;短期使用者和对照组之间没有差异。与对照组相比，长期使用者表现出学习（P= 0.007）、记忆（P= 0.003）和检索（P= 0.002）受损。两个用户组在时间估计任务上的表现都很差（P
Context Cognitive impairments are associated with long-term cannabis use, but the parameters of use that contribute to impairments and the nature and endurance of cognitive dysfunction remain uncertain.Objective To examine the effects of duration of cannabis use on specific areas of cognitive functioning among users seeking treatment for cannabis dependence.Design, Setting, and Participants Multisite retrospective cross-sectional neuropsychological study conducted in the United States (Seattle, Wash; Farmington, Conn; and Miami, Fla) between 1997 and 2000 among 102 near-daily cannabis users (51 long-term users: mean, 23.9 years of use; 51 shorter-term users: mean, 10.2 years of use) compared with 33 nonuser controls.Main Outcome Measures Measures from 9 standard neuropsychological tests that assessed attention, memory, and executive functioning, and were administered prior to entry to a treatment program and following a median 17-hour abstinence.Results Long-term cannabis users performed significantly less well than shorter-term users and controls on tests of memory and attention. On the Rey Auditory Verbal Learning Test, long-term users recalled significantly fewer words than either shorter-term users (P=.001) or controls (P=.005); there was no difference between shorter-term users and controls. Long-term users showed impaired learning (P=.007), retention (P=.003), and retrieval (P=.002) compared with controls. Both user groups performed poorly on a time estimation task (P