New evidence that the MHC influences odor perception in humans: a study with 58 Southern Brazilian students
New evidence that the MHC influences odor perception in humans: a study with 58 Southern Brazilian students
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DOI：
10.1016/j.yhbeh.2004.11.005
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发表时间：
2005-04-01
影响因子：
3.5
通讯作者：
Bicalho, MD
中科院分区：
文献类型：
--
作者：
Santos, PSC;Schinemann, JA;Bicalho, MD
越来越多的证据表明，在包括人类在内的各种动物中，配偶选择、气味偏好和主要组织相容性复合体（MHC）的遗传相似性之间存在相关性。MHC是一组高度多态性的基因，在免疫自我/非自我识别中起重要作用。据报道，它的产品参与了多种化合物和反应，这些化合物和反应共同形成了个人的体味。因此，有人提出，动物利用体味作为一种指南，来识别与自身基因型相似或不同的mhc可能的配偶。选择一个mfic不相似的伴侣可以提高后代的MHC杂合性。可能的适应性优势很明显：这是一种避免近亲繁殖的机制，mhc杂合后代可能具有增强的免疫能力。本研究的目的是在我们的物种中寻找HLA-A和HLA-B特异性与对特定体味的愉悦性评估之间相关性的新证据。HLA是人类MHC的名称。研究人员对58名巴西南部的年轻学生进行了四次嗅觉测试，目的是调查个体对体味的愉悦程度是否与人的HLA表型相关。通过汗液和尿液收集所有参与者的体味。女性闻所有男性气味样本并打分，男性对所有女性样本也做同样的事情。只有当女性嗅觉者评估男性汗味时，我们才发现了显著的相关性。(c) 2004 Elsevier Inc.版权所有。
Increasing evidence suggests a correlation between mate choice, odor preference, and genetic similarity at the Major Histocompatibility Complex (MHC) in a variety of animals, including our species. The MHC is a highly polymorphic group of genes that play an important role in the immunological self/nonself recognition. Its products have been reported to take part on the variety of compounds and reactions that together build an individual's body odor. It has been suggested, therefore, that animals use body odor as a guide to identify possible mates as MHC-similar or MHC-dissimilar from their own genotype. Preference for a MFIC-dissimilar partner enhances MHC heterozygosity of an individual's offspring. The possible adaptive advantages are clear: it is a mechanism of avoiding inbreeding and MHC-heterozygous offspring may have enhanced immunocompetence. The aim of this study was to search, in our species, new evidence on the correlation between specificities at HLA-A and HLA-B and assessments of pleasantness regarding specific body odors. HLA is the name for the human MHC. Four olfactory sessions were performed with 58 young Southern Brazilian students, in order to investigate whether assessments of pleasantness of body odors from individuals correlate to a person's HLA phenotype. Body odors were collected via sweat and urine from all participants. Women smelled and scored all male odor samples and men did the same with all female samples. We found a significant correlation only when female smellers evaluated male sweat odors. (c) 2004 Elsevier Inc. All rights reserved.