Fatty liver diseases, mechanisms, and potential therapeutic plant medicines
Fatty liver diseases, mechanisms, and potential therapeutic plant medicines
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脂肪肝疾病、机制和潜在的治疗植物药物
DOI：
10.1016/s1875-5364(20)30017-0
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发表时间：
2020-03-01
影响因子：
4.6
通讯作者：
Wu Xu-Dong
中科院分区：
文献类型：
--
作者：
Zhu Jia-Zhen;Yi Hong-Wei;Wu Xu-Dong
肝脏是重要的代谢器官，掌控着脂质、葡萄糖和能量代谢。肝脏脂质代谢紊乱常与脂肪性肝病相关，包括非酒精性脂肪性肝病（NAFLD）、酒精性脂肪性肝病（AFLD）以及高脂血症。近期研究揭示了激素、转录因子和炎性细胞因子在血脂异常和脂肪性肝病发病机制中的作用。此外，人们投入了大量精力研究多种天然植物产物对脂肪性肝病和代谢性疾病潜在治疗作用的相关机制。我们综述了目前对胰岛素、甲状腺激素和炎性细胞因子在调节肝脏脂质代谢方面的认识，重点关注几个关键的转录调节因子，如沉默调节蛋白（SIRTs）、叉头框蛋白O（FoxO）、固醇调节元件结合蛋白（SREBPs）。我们还讨论了几种对脂肪性肝病和血脂异常具有良好治疗效果的代表性天然产物。
The liver is an important metabolic organ and controls lipid, glucose and energy metabolism. Dysruption of hepatic lipid metabolism is often associated with fatty liver diseases, including nonalcoholic fatty liver disease (NAFLD), alcoholic fatty liver diseases (AFLD) and hyperlipidemia. Recent studies have uncovered the contribution of hormones, transcription factors, and inflammatory cytokines to the pathogenesis of dyslipidemia and fatty liver diseases. Moreover, a significant amount of effort has been put to examine the mechanisms underlying the potential therapeutic effects of many natural plant products on fatty liver diseases and metabolic diseases. We review the current understanding of insulin, thyroid hormone and inflammatory cytokines in regulating hepatic lipid metabolism, focusing on several essential transcription regulators, such as Sirtuins (SIRTs), Forkhead box O (FoxO), Sterol-regulatory element-binding proteins (SREBPs). We also discuss a few representative natural products with promising thereapeutic effects on fatty liver disease and dyslipidemia.