COMPLEMENT FACTORS IN GINGIVAL CREVICE MATERIAL FROM HEALTHY AND INFLAMED GINGIVA IN HUMANS
COMPLEMENT FACTORS IN GINGIVAL CREVICE MATERIAL FROM HEALTHY AND INFLAMED GINGIVA IN HUMANS
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DOI：
10.1111/j.1600-0765.1975.tb00003.x
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发表时间：
1975-01-01
影响因子：
3.5
通讯作者：
SJOHOLM, A
中科院分区：
文献类型：
--
作者：
ATTSTROM, R;LAUREL, AB;SJOHOLM, A
补体因子C3，C4，C5和C3前激活剂的存在和水平，通过电免疫测定法确定从5个人与健康牙龈和6例慢性牙龈炎患者的牙龈缝隙材料。与健康牙龈的样本相比，慢性炎症牙龈的样本中C3和C4的浓度更高。以血浆和龈沟材料中的白蛋白为参照，健康牙龈和炎症牙龈材料中的C3含量与血浆中的C3含量相关。在健康牙龈的样本中也发现了同样的C4，但在发炎牙龈的样本中，当与血浆水平相关时，该值显着降低。C5不能被发现在材料从健康牙龈，但存在于材料从发炎牙龈。C3前激活剂存在于转化形式的发炎牙龈材料中。结果表明，在正常牙龈组织中未发现补体C3前激活物，而在炎症牙龈组织中，补体C3发生了转化，提示炎症牙龈组织中补体系统可能被激活。
The presence and levels of complement factors C3, C4, C5, and C3 proactivator, were determined by electroimmuno assay in gingival crevice material from five individuals with healthy gingiva and from six patients with chronically inflamed gingiva. Higher concentrations of C3 and C4 were found in samples from chronically inflamed gingiva when compared to those from healthy gingiva. The amount of C3 in material from healthy as well as from inflamed gingiva was related to that in plasma, when the albumin in plasma and gingival crevice material was used as a reference. The same was found for C4 in samples from healthy gingiva but in those from inflamed gingiva, the values were significantly lower when related to plasma levels. C5 could not be found in material from healthy gingiva but was present in material from inflamed gingiva. C3 proactivator was present in material from inflamed gingiva in the converted form. No C3 proactivator was found in material from healthy gingiva with the methods used.Analysis of C3 in samples from inflamed gingiva, using crossed immunoelectrophoresis, showed that C3 was converted in these samples.The results indicate that the complement system may be activated in gingival crevice material from inflamed gingiva.