Effect of physical exercise on seizure occurrence in a model of temporal lobe epilepsy in rats
Effect of physical exercise on seizure occurrence in a model of temporal lobe epilepsy in rats
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DOI：
10.1016/s0920-1211(99)00032-7
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发表时间：
1999-10-01
影响因子：
2.2
通讯作者：
Cavalheiro, EA
中科院分区：
文献类型：
--
作者：
Arida, RM;Scorza, FA;Cavalheiro, EA
尽管身体健康对整体健康的有利作用是毋庸置疑的，但癫痫患者的体育锻炼和健身计划仍然是一个有争议的问题。关于运动对癫痫发作频率和严重程度的影响的客观证据很少有报道。其中一项研究试图在颞叶癫痫动物模型(匹罗卡品癫痫模型)中阐明运动与癫痫之间的关系。为了评价有氧运动对癫痫发作频率的影响，29只癫痫动物在首次自发性反复发作(SRS)后24小时内连续监测135天，分为3组。第一组(N=14)接受有氧运动计划(训练组)。第二组(N=7)与训练组在跑台上保持相同的时间，不进行体育锻炼(假手术组)。第三组(N=8)为对照组。行为观察分三期进行，每期45天。第一阶段用于确定运动前的癫痫发作次数。第二阶段被用来确定体育训练期间的癫痫发作次数。第三个时段用于分析运动训练后癫痫发作的频率。对照组和假手术组大鼠癫痫发作次数在第1~2期和第1~第3期显著增加，而训练组在45d的3个观察期之间无明显变化。同时分析三组相同时间段时，训练组与对照组和假手术组相比，运动训练期间癫痫发作频率明显减少。这项研究提供的数据表明，在这个癫痫的实验模型中，体育锻炼不是一个诱发癫痫的因素。(C)1999 Elsevier Science B.V.保留所有权利。
Although the favorable effect of physical fitness on general health is unquestionable, physical exercise and fitness programs in patients with epilepsy are still a matter of controversy. Little objective evidence regarding the effect of exercise on seizure frequency and severity has been reported. One sought to clarify the relationship between exercise and epilepsy in an animal model of temporal lobe epilepsy (the pilocarpine model of epilepsy). To evaluate the effect of an aerobic physical program on seizure frequency, 29 epileptic animals were continuously monitored during 24 h for 135 days after the first spontaneous recurrent seizure (SRS) and divided into three groups. The first group (N = 14) was submitted to an aerobic exercise program (training group). The second group (N = 7) was maintained in the treadmill for the same time as the training group without being submitted to physical exercise (sham group). The third group (N = 8) served as control. The behavioral observation was divided in three periods of 45 days. The first period was used to determine the number of seizures before physical training program. The second period was utilized to determine the number of seizures during the physical training program. The third period was used to analyze the frequency of seizures after the physical training program. The mean frequency of seizures in the control and sham groups increased significantly from period 1 to period 2 and from period 1 to period 3. However, in the training group, the frequency of seizures did not change significantly between the three periods of 45 days of observation. When the same periods of the three groups were analyzed together, a significant reduction in seizure frequency was observed comparing the training group with the control and sham groups during the period of physical training. The data presented in this study suggest that physical exercise is not a seizure-inducing factor in this experimental model of epilepsy. (C) 1999 Elsevier Science B.V. All rights reserved.