Analysis of Inlet Velocity Profiles in Numerical Assessment of Fontan Hemodynamics.
Analysis of Inlet Velocity Profiles in Numerical Assessment of Fontan Hemodynamics.
复制标题
Fontan 血流动力学数值评估中入口速度剖面分析。
DOI：
10.1007/s10439-019-02307-z
复制
发表时间：
2019
影响因子：
3.8
通讯作者：
Yoganathan,AjitP
中科院分区：
文献类型：
--
作者：
Wei,ZhenglunAlan;Huddleston,Connor;Trusty,PhillipM;Singh-Gryzbon,Shelly;Fogel,MarkA;Veneziani,Alessandro;Yoganathan,AjitP
Computational fluid dynamic (CFD) simulations are widely utilized to assess Fontan hemodynamics that are related to long-term complications. No previous studies have systemically investigated the effects of using different inlet velocity profiles in Fontan simulations. This study implements real, patient-specific velocity profiles for numerical assessment of Fontan hemodynamics using CFD simulations. Four additional, artificial velocity profiles were used for comparison: (1) flat, (2) parabolic, (3) Womersley, and (4) parabolic with inlet extensions [to develop flow before entering the total cavopulmonary connection (TCPC)]. The differences arising from the five velocity profiles, as well as discrepancies between the real and each of the artificial velocity profiles, were quantified by examining clinically important metrics in TCPC hemodynamics: power loss (PL), viscous dissipation rate (VDR), hepatic flow distribution, and regions of low wall shear stress. Statistically significant differences were observed in PL and VDR between simulations using real and flat velocity profiles, but differences between those using real velocity profiles and the other three artificial profiles did not reach statistical significance. These conclusions suggest that the artificial velocity profiles (2)–(4) are acceptable surrogates for real velocity profiles in Fontan simulations, but parabolic profiles are recommended because of their low computational demands and prevalent applicability.
