Advances in Recurrent Stroke Prevention: Focus on Antithrombotic Therapies.
Advances in Recurrent Stroke Prevention: Focus on Antithrombotic Therapies.
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DOI：
10.1161/circresaha.121.319947
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发表时间：
2022-04-15
影响因子：
20.1
通讯作者：
Chaturvedi, Seemant
中科院分区：
文献类型：
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作者：
Mac Grory, Brian;Yaghi, Shadi;Cordonnier, Charlotte;Sposato, Luciano A.;Romano, Jose G.;Chaturvedi, Seemant
在过去的十年中，中风预防取得了重大进展。这些进展包括新的抗血栓药物，血脂异常治疗的新选择，以及外科卒中预防的新技术。此外，人们更加认识到多方面干预措施的好处，包括体育活动和饮食调整的作用。尽管取得了这些进展，但人口老龄化和关键血管危险因素的高患病率对降低卒中负担提出了挑战。本文采用病因学为基础的框架，概述了目前预防心源性、隐源性、动脉粥样硬化性和小血管疾病性卒中的方法。特别强调抗血栓药物的最新试验，包括根据遗传因素测试组合治疗和反应的研究。
The past decade has seen significant advances in stroke prevention. These advances include new antithrombotic agents, new options for dyslipidemia treatment, and novel techniques for surgical stroke prevention. In addition, there is greater recognition of the benefits of multi-faceted interventions, including the role of physical activity and dietary modification. Despite these advances, the aging of the population and the high prevalence of key vascular risk factors pose challenges to reducing the burden of stroke. Using an etiology-based framework, current approaches to prevention of cardioembolic, cryptogenic, atherosclerotic, and small vessel disease stroke are outlined in this paper. Special emphasis is given to recent trials of antithrombotic agents, including studies that have tested combination treatments and response according to genetic factors.