Kaposi sarcoma-associated herpesvirus/human herpesvirus 8-associated lymphoproliferative disorders
Kaposi sarcoma-associated herpesvirus/human herpesvirus 8-associated lymphoproliferative disorders
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DOI：
10.1182/blood-2018-11-852442
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发表时间：
2019-03-14
期刊：
影响因子：
20.3
通讯作者：
Galicier, Lionel
中科院分区：
文献类型：
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作者：
Oksenhendler, Eric;Boutboul, David;Galicier, Lionel
卡波西肉瘤相关疱疹病毒/人类疱疹病毒8型与多中心性Castleman病(MCD)和原发性渗出性淋巴瘤(PEL)有关。在MCD中，感染的B细胞虽然是多克隆的，但表达单型免疫球蛋白M1表型，可能是通过编辑成熟B细胞中的lambda轻链来实现的。它们被认为起源于生发中心(GC)前幼稚B细胞。病毒和人白介素6都有助于这些细胞的浆细胞分化，在一些感染的细胞中可以观察到病毒复制。PEL细胞是克隆性B细胞，被认为是GC/GC后B细胞。人们还可以假设它们起源于相同的受感染的幼稚B细胞，其他因素可能是它们特殊表型的原因。
Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 is associated with multicentric Castleman disease (MCD) and primary effusion lymphoma (PEL). In MCD, infected B cells, although polyclonal, express a monotypic immunoglobulin Ml phenotype, probably through editing toward lambda light chain in mature B cells. They are considered to originate from pre-germinal center (GC) naive B cells. Both viral and human interleukin-6 contribute to the plasmacytic differentiation of these cells, and viral replication can be observed in some infected cells. PEL cells are clonal B cells considered as GC/post-GC B cells. One can also hypothesize that they originate from the same infected naive B cells and that additional factors could be responsible for their peculiar phenotype.