Alleviation of Polycation-Induced Blood Coagulation by the Formation of Polypseudorotaxanes with Macrocyclic Cucurbit[7]uril
Alleviation of Polycation-Induced Blood Coagulation by the Formation of Polypseudorotaxanes with Macrocyclic Cucurbit[7]uril
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DOI：
10.1021/acsabm.8b00401
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发表时间：
2018-09-17
影响因子：
4.7
通讯作者：
Wang, Ruibing
中科院分区：
文献类型：
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作者：
Huang, Quoxian;Cheng, Qian;Wang, Ruibing
溴化己二甲铵 (HB) 是一种中和肝素并控制内出血的聚阳离子，也可能导致严重的血液凝固，从而危及生命。肝素逆转 HB，反之亦然，可能会导致替代性出血和血液凝固的恶性循环。在这封信中，一种生物相容性合成纳米受体葫芦[7]uril (CB[7])被证明可以通过形成HB@CB[7]聚拟轮烷，在体外和体内显着减轻HB诱导的凝血。这一发现首次表明合成受体在减轻聚阳离子药物的副作用和毒性方面具有显着的临床潜力。
Hexadimethrine bromide (HB), a polycation to neutralize heparin and control internal bleeding, may also cause serious blood coagulation that may be life-threatening. Reversal of HB by heparin and vice versa might potentially lead to a vicious circle of alternative bleeding and blood coagulation. In this Letter, a biocompatible synthetic nano-receptor, cucurbit[7]uril (CB[7]), was demonstrated to dramatically alleviate HB-induced blood coagulation in vitro as well as in vivo, through the formation of HB@CB[7] polypseudorotaxanes. This discovery, for the first time, suggests the significant clinical potential of a synthetic receptor in alleviating the side effects and toxicity of a polycationic drug.