Lesions targeted to the anterior forebrain disrupt vocal variability associated with testosterone-induced sensorimotor song development in adult female canaries, Serinus canaria.
Lesions targeted to the anterior forebrain disrupt vocal variability associated with testosterone-induced sensorimotor song development in adult female canaries, Serinus canaria.
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DOI：
10.1002/dneu.22295
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发表时间：
2016-01
影响因子：
3
通讯作者：
Ball GF
中科院分区：
文献类型：
--
作者：
Rouse ML Jr;Ball GF
习得性交流是一种在有限数量的脊椎动物中观察到的特征，例如人类，但也有鸣禽（即有时被称为鸣禽的雀形目）。在一些鸣禽物种中，已经观察到了雄性偏向的性别差异。然而，在这些物种中的一些中，用睾酮（T）治疗成年雌性会引起神经行为变化，使得雌性在大脑和行为上变得更像雄性。在这些成年女性的T-治疗似乎刺激感觉运动歌曲的发展，以促进歌曲男性化。在雄性鸣禽中，前巢皮层外侧大细胞核（LMAN）在鸣唱发育过程中起着调节作用。LMAN是雄激素敏感的，可能是成年女性发育过程中T诱导重演的关键靶点。我们测试了这个假设。成年雌性金丝雀给予LMAN的化学损伤或对照假手术。在手术之前，将鸟单独圈养在声音衰减室中两周以记录基线发声行为。在皮下植入填充有晶体-T的硅橡胶胶囊之前，给予术后鸡一周的恢复时间。鸡只继续接受治疗三周（行为记录持续进行）。与对照组相比，LMAN病变的鸟类在歌声中的变异性较小。假手术对照组的音节和短语类型的多样性高于LMAN病变组。鸟类没有不同的歌曲率。这些数据表明，在成年雌性金丝雀T诱导的感觉运动歌曲的发展的sustention和结论需要一个完整的LMAN。
Learned communication is a trait observed in a limited number of vertebrates such as humans but also songbirds (i.e. species in the suborder passeri sometimes called oscines). Robust male-biased sex-differences in song development and production have been observed in several songbird species. However, in some of these species treating adult females with testosterone (T) induces neuro-behavioral changes such that females become more male-like in brain and behavior. T-treatment in these adult females seems to stimulate sensorimotor song development to facilitate song masculinization. In male songbirds it is known that the lateral magnocellular nucleus of the anterior nidopallium (LMAN) plays a modulatory role during song development. LMAN is androgen sensitive and may be a key target of a T-induced recapitulation of a developmental process in adult females. We tested this hypothesis. Adult female canaries were given either a chemical lesion of LMAN or a control sham-surgery. Prior to surgery birds were individually housed for two-weeks in sound-attenuated chambers to record baseline vocal behavior. Post-surgery birds were given one-week to recover before subcutaneous implantation with silastic capsules filled with crystalline-T. Birds remained on treatment for three-weeks (behavioral recordings continued throughout). Birds with a lesion to LMAN had less variability in their song compared to controls. The diversity of syllable and phrase type(s) was greater in sham controls as compared to birds with LMAN lesions. Birds did not differ in song rate. These data suggest that the sustention and conclusion of T-induced sensorimotor song development in adult female canaries requires an intact LMAN.