Cognitive correlates of apathy in traumatic brain injury
Cognitive correlates of apathy in traumatic brain injury
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DOI：
10.1097/01.wnn.0000026596.88167.8e
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发表时间：
2002-09-01
期刊：
影响因子：
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通讯作者：
Bergedalen, AM
中科院分区：
文献类型：
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作者：
Andersson, S;Bergedalen, AM
目的：探讨重型颅脑损伤患者的冷漠与认知功能障碍的关系。背景：冷漠是指因缺乏动力而导致的目标导向行为减少，是重型颅脑损伤后的主要神经精神症状。根据定义，冷漠不应与整体认知功能下降相关，而应与特定认知功能障碍相关。方法：收集53例重型颅脑损伤患者的冷漠评定量表(AES)和综合神经心理学评估结果。在认知功能的7个方面进行神经心理学测试：获得和记忆、注意广度、执行功能、精神运动速度、语言技能、非语言技能和运动速度。结果：冷漠得分与在获取和记忆、精神运动速度和执行功能方面的表现下降显著相关。主成分分析表明，这些特定的认知功能区域与冷漠的认知维度聚集在一起，而不是与冷漠的行为或情感方面聚集在一起，结论：冷漠与额叶功能障碍相关的特定认知缺陷有关。这一结果与冷漠的定义一致，并证实了在其他神经学人群中报道的冷漠-认知功能关系。
Objective: To investigate the relation between apathy and cognitive deficits in patients with severe traumatic brain injury (TBI).Background: Apathy defined as reduced goal-directed behavior due to lack of motivation constitutes a major neuropsychiatric symptom following TBI. According to definition, apathy should not be associated with global cognitive reduction, but rather with specific areas of cognitive dysfunction.Methods: Results from the Apathy Evaluation Scale (AES) and a comprehensive neuropsychologic assessment were collected in up to 53 patients With severe TBI. Neuropsychologic tests were organized in the following seven areas of cognitive function: acquisition and memory, attention span, executive function, psychomotor speed, verbal skills, nonverbal skills, and motor speed.Results: Apathy score was significantly correlated with reduced performance on acquisition and memory, psychomotor speed, and executive functions. A principal component analysis showed that these specific areas of cognitive functions clustered together with the cognitive dimension of apathy, not with behavioral or emotional aspects of apathy,Conclusions: Apathy is associated with specific cognitive deficits related to frontal lobe dysfunction. The results are in accordance with the definition of apathy and confirm apathy-cognitive function relationships reported in other neurologic populations.