A role for eosinophils in airway remodelling in asthma
A role for eosinophils in airway remodelling in asthma
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DOI：
10.1016/j.it.2004.07.006
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发表时间：
2004-09-01
影响因子：
16.8
通讯作者：
Robinson, DS
中科院分区：
文献类型：
--
作者：
Kay, AB;Phipps, S;Robinson, DS
多年来，嗜酸性粒细胞在哮喘和过敏过程中的作用一直存在争议。最近使用人源化白细胞介素-5 （IL-5）单克隆抗体的人体实验，以及涉及特异性IL-5基因缺失的动物研究表明，嗜酸性粒细胞可能控制下游修复和重塑过程。嗜酸性粒细胞是纤维生成因子的丰富来源，尤其是转化生长因子- β (tgf - β)，其潜伏形式可通过上皮细胞间素α (v) β的表达激活(6)。嗜酸性粒细胞在气道重塑中的新作用可能对未来的抗哮喘策略很重要。然而，在确定这种细胞类型在哮喘气道病理生理中的明确作用之前，需要比抗il- 5更有效的嗜酸性粒细胞消耗剂。
Over the years, the role of the eosinophil in asthma and allergic processes has been disputed. Recent human experiments using a humanised monoclonal antibody to interieukin-5 (IL-5), and animal studies involving specific IL-5 gene deletion, indicates that eosinophils might control downstream repair and remodelling processes. Eosinophils are a rich source of fibrogenic factors, particularly transforming growth factor-beta (TGF-beta), the latent form of which is activated by epithelial-cell expression of the intergin alpha(v)beta(6). The emerging role for the eosinophill in airway remodelling might be important in future anti-asthma strategies. However, more effective eosinophil-depleting agents than anti-IL-5 are required before the definitive role of this cell type in asthma airway pathophysiology can be established.