Adhesion of osteoblasts to a nanorough titanium implant surface.
Adhesion of osteoblasts to a nanorough titanium implant surface.
复制标题
DOI：
10.2147/ijn.s21755
复制
发表时间：
2011
影响因子：
8
通讯作者：
Iglič A
中科院分区：
文献类型：
--
作者：
Gongadze E;Kabaso D;Bauer S;Slivnik T;Schmuki P;van Rienen U;Iglič A
这项工作考虑了细胞与纳米级钛植入物表面的粘附性。基本假设是，带负电荷的钛表面和带负电荷的成骨细胞之间的吸引力是由具有独特的四极内部电荷分布的带电蛋白介导的。同样，由于表面电荷密度高，纤维连接蛋白分子与钛表面之间阳离子介导的吸引力预计会更有效，从而促进整合素介导的成骨细胞粘附。我们认为，成骨细胞在纳米级钛表面的尖锐凸边或尖峰处结合最强烈，那里的负电荷密度最大。因此，具有锋利边缘和尖刺的钛表面的纳米级区域促进成骨细胞的粘附是合理的。
This work considers the adhesion of cells to a nanorough titanium implant surface with sharp edges. The basic assumption was that the attraction between the negatively charged titanium surface and a negatively charged osteoblast is mediated by charged proteins with a distinctive quadrupolar internal charge distribution. Similarly, cation-mediated attraction between fibronectin molecules and the titanium surface is expected to be more efficient for a high surface charge density, resulting in facilitated integrin mediated osteoblast adhesion. We suggest that osteoblasts are most strongly bound along the sharp convex edges or spikes of nanorough titanium surfaces where the magnitude of the negative surface charge density is the highest. It is therefore plausible that nanorough regions of titanium surfaces with sharp edges and spikes promote the adhesion of osteoblasts.