The Gut Microbiota Impact Cancer Etiology through "Phase IV Metabolism" of Xenobiotics and Endobiotics.
The Gut Microbiota Impact Cancer Etiology through "Phase IV Metabolism" of Xenobiotics and Endobiotics.
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DOI：
10.1158/1940-6207.capr-20-0155
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发表时间：
2020-08
期刊：
影响因子：
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通讯作者：
Redinbo MR
中科院分区：
文献类型：
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作者：
Ervin SM;Redinbo MR
人类肠道微生物组与人类基因组密切互补，肠道微生物因子直接影响健康和疾病。在这里，我们概述了肠道微生物群如何通过加工人类药物和内生代谢的产物而对癌症病因做出独特的贡献。我们正式提出，肠道微生物群进行的反应应被归类为“第四阶段异生物质和内源性代谢”。最后，我们讨论了通过抑制负责肿瘤发生和发展的肠道微生物IV相酶来控制癌症的新数据。
The human gut microbiome intimately complements the human genome and gut microbial factors directly influence health and disease. Here we outline how the gut microbiota uniquely contributes to cancer etiology by processing products of human drug and endobiotic metabolism. We formally propose that the reactions performed by the gut microbiota should be classified as “Phase IV xenobiotic and endobiotic metabolism.” Finally, we discuss new data on the control of cancer by the inhibition of gut microbial phase IV enzymes responsible for tumor initiation and progression.