High-dose Bisacodyl Plus Water Lavage Compared With Oral Sodium Phosphate as Bowel Preparation for Outpatient Colonoscopy
High-dose Bisacodyl Plus Water Lavage Compared With Oral Sodium Phosphate as Bowel Preparation for Outpatient Colonoscopy
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DOI：
10.1016/s1726-4901(09)70396-x
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发表时间：
2009-08-01
影响因子：
3
通讯作者：
Lai, Kwok-Hung
中科院分区：
文献类型：
--
作者：
Chen, Tai-An;Wong, Hsin-Yung;Lai, Kwok-Hung
背景资料：这项前瞻性研究的目的是比较口服高剂量比沙可啶加水灌洗和口服磷酸钠在接受择期结肠镜检查的成人中的疗效和患者依从性。方法：共有276例患者随机接受口服高剂量比沙可啶制剂（6片5 mg比沙可啶）加水灌洗（2 L水）或口服磷酸钠（NaP）制剂（90 mL，分次给药）。所有内窥镜手术均在下午进行。内窥镜医师对患者接受的准备不知情，并将结肠清洁质量分级为极好、良好、一般、差或失败。记录并比较患者的人口统计学数据、手术适应症和结肠镜检查结果。结果：NaP后肠道准备与比沙可啶加水灌洗相比有显著改善（p < 0.001）。比沙可啶组结肠镜检查完成率（70.6%）显著低于NaP组（92.9%）（p < 0.001）。与比沙可啶组（27.1%）相比，NaP组（43.1%）的息肉检出率显著增加（p=0.017）。便秘指征是比沙可啶组肠道准备失败的独立预测因素（比值比，4.8; 95%可信区间，1.9-12.0; p < 0.001）。结论：口服NaP的肠道准备质量优于比沙可啶加水灌洗。[中华医学杂志2009;72（8）：402-407]
Background: The aim of this prospective study was to compare the efficacy and patient compliance of an oral high dose of bisacodyl plus water lavage and oral sodium phosphate in adults undergoing elective colonoscopy.Methods: A total of 276 patients were randomized to receive an oral high-dose bisacodyl preparation (6 tablets of 5 mg bisacodyl) plus water lavage (2 L of water) or an oral sodium phosphate (NaP) preparation (90 mL in divided doses). All endoscopic procedures were conducted in the afternoon. The endoscopist was blinded to the preparation the patient had received and graded the quality of colon cleansing as excellent, good, fair, poor, or failed. Patients' demographic data, indications for the procedure, and colonoscopic findings were recorded and compared.Results: Significantly improved (p < 0.001) bowel preparation after NaP compared with bisacodyl plus water lavage was reported. The completion rate of colonoscopy was significantly lower (p < 0.001) in the bisacodyl group (70.6%) than in the NaP group (92.9%). The detection of polyps was significantly increased (p=0.017) in the NaP group (43.1%) compared with the bisacodyl group (27.1%). A procedural indication of constipation was an independent predictor of failed preparation in the bisacodyl group (odds ratio, 4.8; 95% confidence interval, 1.9-12.0; p < 0.001).Conclusion: The quality of bowel preparation with oral NaP was better than that with bisacodyl plus water lavage. [J Chin Med Assoc 2009;72(8):402-407]