Tandem Chloropalladation/Cyclization and Dearomative Cyclization toward Functionalized Tricyclic Bridged [3.2.1] Skeleton Compounds.
Tandem Chloropalladation/Cyclization and Dearomative Cyclization toward Functionalized Tricyclic Bridged [3.2.1] Skeleton Compounds.
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DOI：
10.1021/acs.orglett.5b02076
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发表时间：
2015-08
期刊：
影响因子：
5.2
通讯作者：
Yi Dong;Nana Du;Xue-yong Li;Litao Zheng;Gang Liu
中科院分区：
文献类型：
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作者：
Yi Dong;Nana Du;Xue-yong Li;Litao Zheng;Gang Liu
报道了一种钯催化的串联反应，该反应涉及氯钯化/环化和脱芳环化以构建三环桥接的[3.2.1]碳环骨架和氧杂-和氮杂-骨架。在这个多米诺骨牌过程中，一定程度的环张力和其他竞争反应，即，在温和的反应条件下，质子分解、β-氢化物消除和C-Pd键的氯化被抑制到最低水平。
A palladium-catalyzed tandem reaction is reported that involves chloropalladation/cyclization and dearomative cyclization to construct a tricyclic bridged [3.2.1] carbocyclic-skeleton and oxa- and aza-skeletons. In this domino process, a level of ring strain and other competitive reactions, i.e., protonolysis, β-hydride elimination, and chlorination of the C-Pd bond, were suppressed to the lowest level under mild reaction conditions.